Setting description

Treatments equally effective across the biomarker signatures

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4 TC5
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
all summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
all effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
AR- & TP53- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
AR- & TP53- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
AR- & TP53- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
HRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
HRD+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
HRD+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
TP53+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
TP53+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
TEfus+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
TEfus+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
PI3K+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
PI3K+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
PI3K+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4 TC5
—– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+— summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+— effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+–+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+-+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+-++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-++– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+–+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+–+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+–++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+–++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++— summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++— effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++–+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++-+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++-++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+++– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 9 7 5 4 6
AR- & TP53- 35 18 16 16 10
HRD+ 10 7 10 13 7
TP53+ 6 5 2 4 4
TEfus+ 2 1 3 3 2
PI3K+ 6 3 5 8 2
TC1 TC2 TC3 TC4 TC5
all 0.018 0.014 0.010 0.008 0.012
AR- & TP53- 0.070 0.036 0.032 0.032 0.020
HRD+ 0.020 0.014 0.020 0.026 0.014
TP53+ 0.012 0.010 0.004 0.008 0.008
TEfus+ 0.004 0.002 0.006 0.006 0.004
PI3K+ 0.012 0.006 0.010 0.016 0.004
futility (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 5 3 0 2 0
AR- & TP53- 77 61 61 53 54
HRD+ 12 9 31 23 10
TP53+ 20 33 18 24 28
TEfus+ 11 14 9 11 9
PI3K+ 22 20 15 18 29
TC1 TC2 TC3 TC4 TC5
all 0.010 0.006 0.000 0.004 0.000
AR- & TP53- 0.154 0.122 0.122 0.106 0.108
HRD+ 0.024 0.018 0.062 0.046 0.020
TP53+ 0.040 0.066 0.036 0.048 0.056
TEfus+ 0.022 0.028 0.018 0.022 0.018
PI3K+ 0.044 0.040 0.030 0.036 0.058
max sample size (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 0 0 0 0 0
AR- & TP53- 45 37 44 30 40
HRD+ 0 0 0 0 0
TP53+ 0 0 0 0 0
TEfus+ 0 0 0 0 0
PI3K+ 0 0 0 0 0
TC1 TC2 TC3 TC4 TC5
all 0.00 0.000 0.000 0.00 0.00
AR- & TP53- 0.09 0.074 0.088 0.06 0.08
HRD+ 0.00 0.000 0.000 0.00 0.00
TP53+ 0.00 0.000 0.000 0.00 0.00
TEfus+ 0.00 0.000 0.000 0.00 0.00
PI3K+ 0.00 0.000 0.000 0.00 0.00


Operating characteristics

char overall TC1 TC2 TC3 TC4 TC5
err_sign 0.3534137 0.1285141 0.0803213 0.0763052 0.0883534 0.062249
err_type 0.3534137 0.1285141 0.0803213 0.0763052 0.0883534 0.062249
pow_sign 0.0000000 0.0000000 0.0000000 0.0000000 0.0000000 0.000000
pow_type 0.0000000 0.0000000 0.0000000 0.0000000 0.0000000 0.000000

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4 TC5
all graduation 0 9 7 5 4 6
all futility 0 5 3 0 2 0
all max_n 0 0 0 0 0 0
all n 357 (322, 402) 170 (105, 225) 164 (111, 218) 159 (109, 217) 162 (112, 212) 170 (114, 220)
all n_unique 327 (295, 369) 156 (95, 207) 150 (100, 200) 144 (97, 201) 147 (102, 196) 154 (104, 202)
all time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
all time_stop NA (NA, NA) 4 (3, 6) 6 (5, 13) 7 (6, 9) 10 (7, 22) 7 (6, 8)
all post_p NA (NA, NA) 0.5 (0.1, 0.89) 0.49 (0.12, 0.88) 0.5 (0.1, 0.87) 0.47 (0.11, 0.89) 0.47 (0.09, 0.89)
all rate 0.112 (0.104, 0.12) 0.113 (0.101, 0.127) 0.112 (0.101, 0.126) 0.113 (0.101, 0.127) 0.113 (0.1, 0.125) 0.113 (0.102, 0.129)
AR- & TP53- graduation 0 35 18 16 16 10
AR- & TP53- futility 0 77 61 61 53 54
AR- & TP53- max_n 0 45 37 44 30 40
AR- & TP53- n 213 (183, 250) 94 (31, 148) 82 (35, 141) 86 (38, 144) 84 (43, 139) 91 (41, 145)
AR- & TP53- n_unique 198 (169, 231) 86 (29, 139) 76 (31, 132) 78 (36, 133) 78 (39, 130) 83 (37, 134)
AR- & TP53- time_trial 36 (36, 36) 36 (9, 36) 36 (17, 36) 36 (21, 36) 36 (22, 36) 36 (23, 36)
AR- & TP53- time_stop NA (NA, NA) 9 (6, 23) 15 (9, 27) 17 (11, 29) 15 (11, 30) 15 (10, 27)
AR- & TP53- post_p NA (NA, NA) 0.5 (0.1, 0.9) 0.48 (0.09, 0.87) 0.48 (0.1, 0.91) 0.49 (0.1, 0.88) 0.45 (0.11, 0.9)
AR- & TP53- rate 0.113 (0.102, 0.124) 0.113 (0.098, 0.139) 0.114 (0.099, 0.139) 0.114 (0.097, 0.137) 0.113 (0.096, 0.14) 0.114 (0.097, 0.138)
HRD+ graduation 0 10 7 10 13 7
HRD+ futility 0 12 9 31 23 10
HRD+ max_n 0 0 0 0 0 0
HRD+ n 58 (46, 70) 25 (10, 38) 26 (14, 39) 32 (20, 47) 32 (20, 47) 27 (15, 41)
HRD+ n_unique 52 (41, 64) 22 (9, 35) 24 (13, 36) 29 (18, 42) 29 (18, 43) 24 (14, 36)
HRD+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
HRD+ time_stop NA (NA, NA) 28 (21, 35) 31 (27, 36) 29 (18, 33) 26 (18, 35) 28 (21, 34)
HRD+ post_p NA (NA, NA) 0.52 (0.14, 0.89) 0.49 (0.16, 0.85) 0.49 (0.12, 0.88) 0.52 (0.11, 0.88) 0.5 (0.16, 0.86)
HRD+ rate 0.114 (0.093, 0.139) 0.113 (0.085, 0.158) 0.116 (0.088, 0.157) 0.114 (0.089, 0.152) 0.113 (0.089, 0.154) 0.113 (0.087, 0.155)
TP53+ graduation 0 6 5 2 4 4
TP53+ futility 0 20 33 18 24 28
TP53+ max_n 0 0 0 0 0 0
TP53+ n 118 (103, 139) 58 (37, 78) 60 (39, 81) 56 (37, 79) 57 (38, 77) 61 (39, 82)
TP53+ n_unique 107 (93, 125) 52 (33, 70) 54 (35, 74) 51 (34, 72) 51 (34, 69) 55 (35, 76)
TP53+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
TP53+ time_stop NA (NA, NA) 21 (14, 28) 19 (13, 28) 23 (18, 31) 23 (14, 34) 18 (13, 31)
TP53+ post_p NA (NA, NA) 0.47 (0.11, 0.87) 0.49 (0.1, 0.88) 0.47 (0.09, 0.86) 0.46 (0.12, 0.86) 0.49 (0.09, 0.89)
TP53+ rate 0.111 (0.098, 0.127) 0.113 (0.094, 0.139) 0.112 (0.094, 0.139) 0.113 (0.095, 0.143) 0.113 (0.094, 0.137) 0.113 (0.093, 0.14)
TEfus+ graduation 0 2 1 3 3 2
TEfus+ futility 0 11 14 9 11 9
TEfus+ max_n 0 0 0 0 0 0
TEfus+ n 112 (98, 130) 53 (34, 71) 59 (42, 78) 56 (40, 74) 56 (39, 73) 60 (41, 79)
TEfus+ n_unique 101 (88, 118) 48 (31, 65) 53 (37, 71) 50 (36, 66) 51 (35, 67) 54 (37, 71)
TEfus+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
TEfus+ time_stop NA (NA, NA) 20 (15, 32) 21 (12, 33) 22 (17, 32) 20 (14, 32) 20 (14, 31)
TEfus+ post_p NA (NA, NA) 0.44 (0.08, 0.84) 0.5 (0.11, 0.88) 0.48 (0.09, 0.87) 0.5 (0.1, 0.89) 0.52 (0.11, 0.88)
TEfus+ rate 0.111 (0.097, 0.128) 0.115 (0.095, 0.144) 0.112 (0.094, 0.135) 0.113 (0.095, 0.138) 0.112 (0.093, 0.138) 0.111 (0.093, 0.134)
PI3K+ graduation 0 6 3 5 8 2
PI3K+ futility 0 22 20 15 18 29
PI3K+ max_n 0 0 0 0 0 0
PI3K+ n 117 (100, 138) 55 (32, 76) 56 (34, 75) 56 (37, 77) 56 (36, 75) 64 (43, 87)
PI3K+ n_unique 106 (92, 124) 50 (28, 69) 50 (30, 68) 51 (33, 70) 51 (33, 69) 58 (40, 79)
PI3K+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
PI3K+ time_stop NA (NA, NA) 23 (14, 31) 20 (12, 31) 23 (15, 29) 21 (15, 29) 16 (10, 27)
PI3K+ post_p NA (NA, NA) 0.47 (0.1, 0.88) 0.48 (0.1, 0.87) 0.48 (0.1, 0.89) 0.51 (0.11, 0.87) 0.46 (0.11, 0.87)
PI3K+ rate 0.112 (0.097, 0.126) 0.114 (0.093, 0.144) 0.113 (0.095, 0.142) 0.113 (0.093, 0.138) 0.114 (0.093, 0.137) 0.112 (0.095, 0.136)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4 TC5
—– graduation 0 43 25 21 20 16
—– futility 0 81 63 61 53 54
—– max_n 0 45 37 44 30 40
—– n 124 (100, 149) 48 (18, 99) 39 (12, 98) 39 (11, 86) 39 (11, 89) 44 (12, 87)
—– n_unique 115 (93, 140) 45 (18, 95) 37 (11, 94) 36 (10, 84) 37 (11, 86) 42 (11, 82)
—– post_p NA (NA, NA) 0.47 (0.09, 0.9) 0.45 (0.09, 0.88) 0.42 (0.1, 0.85) 0.44 (0.09, 0.85) 0.43 (0.11, 0.89)
—– rate 0.114 (0.1, 0.128) 0.116 (0.097, 0.153) 0.117 (0.098, 0.175) 0.117 (0.095, 0.178) 0.119 (0.095, 0.176) 0.119 (0.095, 0.175)
—-+ graduation 0 48 28 26 26 17
—-+ futility 0 96 77 66 67 72
—-+ max_n 0 45 36 44 30 40
—-+ n 29 (20, 38) 9 (3, 25) 10 (3, 23) 11 (3, 25) 11 (3, 25) 12 (6, 26)
—-+ n_unique 27 (18, 36) 9 (3, 23) 9 (3, 21) 10 (2, 24) 10 (3, 23) 11 (5, 24)
—-+ post_p NA (NA, NA) 0.47 (0.15, 0.83) 0.47 (0.19, 0.84) 0.46 (0.17, 0.86) 0.49 (0.17, 0.87) 0.43 (0.15, 0.83)
—-+ rate 0.113 (0.085, 0.149) 0.123 (0.083, 0.277) 0.121 (0.079, 0.248) 0.125 (0.08, 0.281) 0.118 (0.079, 0.282) 0.125 (0.085, 0.219)
—+- graduation 0 44 26 23 22 18
—+- futility 0 90 69 68 58 60
—+- max_n 0 45 37 44 30 40
—+- n 5 (2, 8) 3 (1, 6) 3 (1, 6) 2 (0, 5) 2 (0, 5) 3 (0, 6)
—+- n_unique 4 (2, 8) 2 (0, 5) 2 (0, 5) 2 (0, 5) 2 (0, 5) 2 (0, 5)
—+- post_p NA (NA, NA) 0.46 (0.27, 0.74) 0.47 (0.28, 0.74) 0.47 (0.28, 0.74) 0.46 (0.28, 0.74) 0.47 (0.29, 0.75)
—+- rate 0.115 (0.054, 0.251) 0.133 (0.057, 0.426) 0.135 (0.056, 0.415) 0.134 (0.045, 0.489) 0.136 (0.049, 0.438) 0.136 (0.053, 0.411)
—++ graduation 0 49 29 28 28 19
—++ futility 0 103 82 72 71 76
—++ max_n 0 45 36 44 30 40
—++ n 13 (8, 19) 5 (1, 12) 5 (1, 11) 5 (2, 12) 5 (1, 11) 7 (3, 14)
—++ n_unique 12 (7, 17) 4 (1, 11) 4 (1, 10) 5 (1, 10) 5 (1, 10) 6 (2, 13)
—++ post_p NA (NA, NA) 0.47 (0.22, 0.81) 0.46 (0.24, 0.81) 0.46 (0.23, 0.82) 0.46 (0.22, 0.81) 0.5 (0.24, 0.82)
—++ rate 0.115 (0.075, 0.178) 0.127 (0.066, 0.313) 0.13 (0.064, 0.382) 0.124 (0.068, 0.3) 0.123 (0.064, 0.386) 0.117 (0.072, 0.244)
–+– graduation 0 15 12 7 7 10
–+– futility 0 25 35 18 24 28
–+– max_n 0 0 0 0 0 0
–+– n 25 (18, 33) 12 (4, 24) 11 (4, 22) 11 (4, 22) 10 (4, 22) 10 (4, 22)
–+– n_unique 23 (16, 31) 11 (4, 22) 10 (3, 20) 10 (3, 20) 10 (3, 20) 10 (3, 20)
–+– post_p NA (NA, NA) 0.48 (0.15, 0.84) 0.46 (0.17, 0.85) 0.46 (0.18, 0.87) 0.45 (0.16, 0.83) 0.47 (0.16, 0.84)
–+– rate 0.112 (0.085, 0.154) 0.119 (0.082, 0.253) 0.121 (0.079, 0.245) 0.122 (0.079, 0.244) 0.122 (0.082, 0.258) 0.122 (0.08, 0.285)
–+-+ graduation 0 19 15 12 15 12
–+-+ futility 0 42 49 30 38 48
–+-+ max_n 0 0 0 0 0 0
–+-+ n 24 (18, 32) 10 (4, 22) 9 (3, 21) 9 (3, 22) 9 (3, 20) 11 (5, 23)
–+-+ n_unique 22 (15, 29) 9 (3, 20) 8 (3, 19) 8 (3, 20) 9 (3, 19) 10 (4, 22)
–+-+ post_p NA (NA, NA) 0.5 (0.18, 0.89) 0.42 (0.16, 0.83) 0.44 (0.16, 0.85) 0.44 (0.17, 0.83) 0.44 (0.16, 0.84)
–+-+ rate 0.112 (0.083, 0.152) 0.118 (0.076, 0.244) 0.128 (0.082, 0.279) 0.126 (0.08, 0.295) 0.125 (0.081, 0.273) 0.124 (0.082, 0.231)
–++- graduation 0 17 12 10 9 12
–++- futility 0 34 45 25 32 33
–++- max_n 0 0 0 0 0 0
–++- n 7 (3, 11) 3 (1, 7) 4 (2, 8) 3 (1, 7) 3 (1, 6) 3 (1, 7)
–++- n_unique 6 (3, 10) 3 (1, 6) 4 (1, 8) 3 (1, 6) 3 (1, 6) 3 (1, 6)
–++- post_p NA (NA, NA) 0.46 (0.26, 0.78) 0.45 (0.24, 0.8) 0.49 (0.27, 0.79) 0.47 (0.25, 0.77) 0.46 (0.27, 0.75)
–++- rate 0.12 (0.062, 0.199) 0.13 (0.059, 0.437) 0.135 (0.062, 0.38) 0.125 (0.048, 0.458) 0.127 (0.059, 0.483) 0.132 (0.06, 0.431)
–+++ graduation 0 21 15 15 16 14
–+++ futility 0 50 58 36 45 52
–+++ max_n 0 0 0 0 0 0
–+++ n 19 (13, 26) 7 (2, 16) 7 (3, 15) 7 (3, 16) 8 (3, 15) 9 (4, 20)
–+++ n_unique 17 (11, 24) 7 (2, 14) 7 (3, 14) 6 (2, 14) 7 (3, 14) 8 (4, 18)
–+++ post_p NA (NA, NA) 0.43 (0.19, 0.8) 0.43 (0.18, 0.81) 0.46 (0.19, 0.81) 0.46 (0.2, 0.83) 0.48 (0.18, 0.84)
–+++ rate 0.11 (0.079, 0.159) 0.131 (0.079, 0.29) 0.127 (0.077, 0.297) 0.125 (0.077, 0.295) 0.127 (0.077, 0.27) 0.119 (0.078, 0.224)
-+— graduation 0 50 30 29 32 22
-+— futility 0 91 71 87 71 63
-+— max_n 0 44 37 43 30 40
-+— n 25 (18, 33) 8 (1, 20) 8 (2, 19) 12 (4, 24) 12 (5, 24) 9 (3, 21)
-+— n_unique 23 (16, 31) 7 (1, 18) 8 (2, 18) 11 (4, 22) 10 (4, 22) 9 (3, 20)
-+— post_p NA (NA, NA) 0.48 (0.18, 0.87) 0.42 (0.17, 0.84) 0.47 (0.18, 0.87) 0.48 (0.17, 0.87) 0.47 (0.18, 0.83)
-+— rate 0.113 (0.085, 0.16) 0.12 (0.077, 0.281) 0.129 (0.078, 0.298) 0.119 (0.081, 0.224) 0.118 (0.084, 0.251) 0.123 (0.079, 0.28)
-+–+ graduation 0 55 33 33 37 23
-+–+ futility 0 106 83 92 84 81
-+–+ max_n 0 44 36 43 30 40
-+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ post_p NA (NA, NA) 0.48 (0.48, 0.48) 0.51 (0.51, 0.51) 0.47 (0.44, 0.59) 0.51 (0.36, 0.55) 0.5 (0.47, 0.53)
-+–+ rate 0.207 (0, 0.8) 0.153 (0.031, 1.603) 0.116 (0, 0.552) 0.124 (0, 2.869) 0.148 (0, 0.815) 0.177 (0, 1.05)
-+-+- graduation 0 51 31 31 34 24
-+-+- futility 0 100 77 93 76 68
-+-+- max_n 0 44 37 43 30 40
-+-+- n 12 (8, 18) 4 (0, 9) 5 (1, 11) 6 (2, 12) 6 (3, 13) 5 (1, 11)
-+-+- n_unique 11 (7, 17) 3 (0, 8) 4 (1, 10) 5 (2, 11) 5 (2, 12) 4 (1, 9)
-+-+- post_p NA (NA, NA) 0.46 (0.21, 0.79) 0.45 (0.21, 0.81) 0.46 (0.22, 0.81) 0.48 (0.22, 0.82) 0.47 (0.24, 0.82)
-+-+- rate 0.115 (0.078, 0.174) 0.132 (0.066, 0.387) 0.128 (0.07, 0.371) 0.125 (0.072, 0.317) 0.125 (0.065, 0.301) 0.122 (0.065, 0.363)
-+-++ graduation 0 56 34 35 39 25
-+-++ futility 0 113 88 97 88 84
-+-++ max_n 0 44 36 43 30 40
-+-++ n 5 (2, 8) 2 (0, 5) 2 (0, 5) 3 (1, 6) 3 (1, 6) 2 (0, 6)
-+-++ n_unique 4 (2, 8) 2 (0, 5) 2 (0, 5) 2 (0, 6) 2 (0, 5) 2 (0, 5)
-+-++ post_p NA (NA, NA) 0.45 (0.29, 0.74) 0.47 (0.28, 0.73) 0.49 (0.28, 0.74) 0.47 (0.25, 0.73) 0.47 (0.28, 0.76)
-+-++ rate 0.12 (0.052, 0.263) 0.141 (0.049, 0.436) 0.133 (0.053, 0.578) 0.119 (0.054, 0.334) 0.13 (0.047, 0.468) 0.141 (0.048, 0.542)
-++– graduation 0 25 19 17 20 17
-++– futility 0 37 42 46 46 37
-++– max_n 0 0 0 0 0 0
-++– n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– post_p NA (NA, NA) 0.51 (0.46, 0.59) NA (NA, NA) 0.48 (0.44, 0.52) 0.49 (0.45, 0.5) 0.5 (0.48, 0.55)
-++– rate 0.166 (0, 0.652) 0.137 (0, 1.18) 0.086 (0, 2.261) 0.126 (0, 0.908) 0.135 (0, 2.885) 0.219 (0, 0.862)
-++-+ graduation 0 29 22 21 26 19
-++-+ futility 0 52 53 58 59 57
-++-+ max_n 0 0 0 0 0 0
-++-+ n 2 (0, 5) 1 (0, 3) 1 (0, 3) 2 (0, 4) 2 (0, 4) 1 (0, 3)
-++-+ n_unique 2 (0, 4) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 4) 1 (0, 3)
-++-+ post_p NA (NA, NA) 0.49 (0.35, 0.7) 0.48 (0.34, 0.7) 0.47 (0.3, 0.67) 0.47 (0.34, 0.71) 0.49 (0.34, 0.7)
-++-+ rate 0.122 (0.037, 0.363) 0.122 (0, 0.474) 0.122 (0, 0.585) 0.134 (0.031, 0.594) 0.132 (0.044, 0.442) 0.132 (0, 0.556)
-+++- graduation 0 27 19 20 22 19
-+++- futility 0 46 52 53 52 41
-+++- max_n 0 0 0 0 0 0
-+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- post_p NA (NA, NA) 0.48 (0.48, 0.48) NA (NA, NA) 0.56 (0.56, 0.56) NA (NA, NA) 0.52 (0.51, 0.52)
-+++- rate 0.175 (0, 0.635) 0.169 (0, 0.752) 0.118 (0, 0.373) 0.142 (0, 0.394) 0.099 (0, 0.279) 0.066 (0, 0.692)
-++++ graduation 0 31 22 24 28 21
-++++ futility 0 60 62 64 64 60
-++++ max_n 0 0 0 0 0 0
-++++ n 2 (1, 5) 1 (0, 3) 1 (0, 3) 2 (0, 4) 2 (0, 4) 1 (0, 4)
-++++ n_unique 2 (0, 5) 1 (0, 3) 1 (0, 3) 2 (0, 4) 2 (0, 4) 1 (0, 3)
-++++ post_p NA (NA, NA) 0.46 (0.32, 0.7) 0.5 (0.34, 0.7) 0.49 (0.32, 0.71) 0.47 (0.32, 0.69) 0.47 (0.32, 0.69)
-++++ rate 0.122 (0.043, 0.324) 0.144 (0, 0.678) 0.123 (0, 0.593) 0.127 (0.032, 0.521) 0.133 (0.032, 0.632) 0.128 (0.029, 0.608)
+—- graduation 0 9 7 5 4 6
+—- futility 0 5 3 0 2 0
+—- max_n 0 0 0 0 0 0
+—- n 5 (2, 8) 3 (1, 5) 3 (1, 6) 2 (1, 5) 2 (1, 5) 2 (1, 5)
+—- n_unique 4 (1, 7) 2 (0, 5) 3 (1, 5) 2 (0, 5) 2 (0, 5) 2 (0, 4)
+—- post_p NA (NA, NA) 0.48 (0.28, 0.74) 0.5 (0.29, 0.75) 0.48 (0.29, 0.75) 0.47 (0.29, 0.71) 0.46 (0.29, 0.71)
+—- rate 0.116 (0.05, 0.249) 0.12 (0.046, 0.393) 0.12 (0.052, 0.347) 0.126 (0.046, 0.44) 0.137 (0.041, 0.603) 0.139 (0.046, 0.591)
+—+ graduation 0 15 10 10 12 8
+—+ futility 0 27 22 15 19 29
+—+ max_n 0 0 0 0 0 0
+—+ n 2 (0, 4) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3)
+—+ n_unique 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3)
+—+ post_p NA (NA, NA) 0.49 (0.35, 0.68) 0.47 (0.34, 0.67) 0.49 (0.33, 0.67) 0.48 (0.36, 0.66) 0.48 (0.34, 0.68)
+—+ rate 0.122 (0, 0.407) 0.121 (0.002, 0.702) 0.133 (0, 0.721) 0.147 (0, 0.533) 0.15 (0, 0.682) 0.138 (0.043, 0.502)
+–+- graduation 0 11 8 8 6 8
+–+- futility 0 16 16 9 12 9
+–+- max_n 0 0 0 0 0 0
+–+- n 7 (4, 12) 4 (1, 7) 5 (2, 9) 3 (1, 7) 3 (1, 7) 4 (1, 7)
+–+- n_unique 7 (3, 11) 3 (1, 7) 4 (1, 8) 3 (1, 6) 3 (1, 6) 3 (1, 7)
+–+- post_p NA (NA, NA) 0.44 (0.24, 0.77) 0.49 (0.24, 0.81) 0.49 (0.26, 0.79) 0.46 (0.27, 0.81) 0.47 (0.26, 0.78)
+–+- rate 0.121 (0.069, 0.216) 0.138 (0.059, 0.434) 0.126 (0.063, 0.308) 0.134 (0.049, 0.379) 0.13 (0.058, 0.466) 0.13 (0.052, 0.458)
+–++ graduation 0 17 11 13 13 10
+–++ futility 0 36 32 23 27 34
+–++ max_n 0 0 0 0 0 0
+–++ n 3 (1, 6) 2 (0, 4) 2 (0, 5) 2 (0, 4) 2 (0, 4) 2 (1, 5)
+–++ n_unique 3 (1, 6) 2 (0, 4) 2 (0, 4) 2 (0, 4) 2 (0, 4) 2 (0, 5)
+–++ post_p NA (NA, NA) 0.47 (0.3, 0.7) 0.48 (0.28, 0.69) 0.48 (0.29, 0.71) 0.48 (0.29, 0.73) 0.47 (0.31, 0.74)
+–++ rate 0.11 (0.041, 0.294) 0.133 (0.044, 0.497) 0.123 (0.036, 0.439) 0.127 (0.044, 0.471) 0.12 (0.028, 0.492) 0.124 (0.045, 0.406)
+-+– graduation 0 15 12 7 7 10
+-+– futility 0 25 35 18 24 28
+-+– max_n 0 0 0 0 0 0
+-+– n 1 (0, 3) 1 (0, 2) 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– n_unique 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– post_p NA (NA, NA) 0.5 (0.38, 0.66) 0.48 (0.37, 0.69) 0.49 (0.38, 0.67) 0.48 (0.36, 0.63) 0.48 (0.37, 0.65)
+-+– rate 0.132 (0, 0.519) 0.123 (0, 0.612) 0.137 (0, 0.519) 0.127 (0, 0.716) 0.14 (0, 0.625) 0.136 (0, 0.616)
+-+-+ graduation 0 19 15 12 15 12
+-+-+ futility 0 42 49 30 38 48
+-+-+ max_n 0 0 0 0 0 0
+-+-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ post_p NA (NA, NA) NA (NA, NA) 0.52 (0.51, 0.53) 0.52 (0.45, 0.58) NA (NA, NA) 0.47 (0.45, 0.49)
+-+-+ rate 0.105 (0.006, 0.518) 0.217 (0, 0.591) 0.1 (0, 0.678) 0.124 (0, 0.956) 0.288 (0, 7.911) 0.119 (0, 0.337)
+-++- graduation 0 17 12 10 9 12
+-++- futility 0 34 45 25 32 33
+-++- max_n 0 0 0 0 0 0
+-++- n 20 (14, 28) 8 (3, 17) 10 (4, 20) 8 (3, 17) 8 (3, 17) 8 (3, 18)
+-++- n_unique 18 (13, 25) 7 (3, 16) 9 (4, 18) 7 (3, 16) 8 (3, 16) 7 (2, 16)
+-++- post_p NA (NA, NA) 0.43 (0.17, 0.81) 0.48 (0.18, 0.85) 0.44 (0.16, 0.81) 0.45 (0.18, 0.83) 0.47 (0.16, 0.81)
+-++- rate 0.11 (0.078, 0.154) 0.124 (0.082, 0.273) 0.118 (0.075, 0.232) 0.129 (0.081, 0.298) 0.124 (0.075, 0.292) 0.119 (0.078, 0.291)
+-+++ graduation 0 21 15 15 16 14
+-+++ futility 0 50 58 36 45 52
+-+++ max_n 0 0 0 0 0 0
+-+++ n 15 (10, 22) 6 (2, 14) 7 (3, 16) 7 (3, 14) 6 (2, 14) 7 (3, 15)
+-+++ n_unique 14 (9, 20) 5 (2, 13) 6 (2, 14) 6 (2, 13) 6 (2, 13) 7 (2, 14)
+-+++ post_p NA (NA, NA) 0.46 (0.2, 0.81) 0.45 (0.18, 0.83) 0.45 (0.21, 0.81) 0.44 (0.19, 0.83) 0.46 (0.19, 0.82)
+-+++ rate 0.112 (0.078, 0.166) 0.125 (0.073, 0.304) 0.123 (0.075, 0.284) 0.124 (0.071, 0.284) 0.125 (0.075, 0.303) 0.125 (0.074, 0.283)
++— graduation 0 19 14 15 17 13
++— futility 0 17 12 31 25 10
++— max_n 0 0 0 0 0 0
++— n 8 (4, 12) 4 (1, 8) 4 (1, 8) 4 (2, 8) 4 (2, 9) 3 (1, 8)
++— n_unique 7 (3, 11) 3 (1, 7) 3 (1, 7) 4 (1, 7) 4 (2, 8) 3 (1, 7)
++— post_p NA (NA, NA) 0.5 (0.27, 0.82) 0.47 (0.26, 0.79) 0.46 (0.23, 0.77) 0.48 (0.22, 0.77) 0.46 (0.25, 0.78)
++— rate 0.118 (0.066, 0.202) 0.122 (0.058, 0.362) 0.126 (0.063, 0.358) 0.127 (0.069, 0.331) 0.129 (0.067, 0.351) 0.134 (0.061, 0.403)
++–+ graduation 0 25 17 19 23 15
++–+ futility 0 37 28 46 41 39
++–+ max_n 0 0 0 0 0 0
++–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ post_p NA (NA, NA) 0.49 (0.49, 0.5) NA (NA, NA) 0.52 (0.48, 0.56) 0.48 (0.45, 0.51) NA (NA, NA)
++–+ rate 0.2 (0.081, 1.331) 0.187 (0.006, 1.875) 0.138 (0.003, 0.328) 0.118 (0, 0.286) 0.131 (0, 0.818) 0.167 (0.065, 2.498)
++-+- graduation 0 21 15 18 19 15
++-+- futility 0 28 25 39 33 18
++-+- max_n 0 0 0 0 0 0
++-+- n 1 (0, 2) 0 (0, 2) 0 (0, 2) 1 (0, 2) 1 (0, 2) 0 (0, 2)
++-+- n_unique 1 (0, 2) 0 (0, 2) 0 (0, 2) 1 (0, 2) 0 (0, 2) 0 (0, 2)
++-+- post_p NA (NA, NA) 0.49 (0.38, 0.64) 0.49 (0.4, 0.62) 0.5 (0.39, 0.61) 0.48 (0.39, 0.62) 0.48 (0.39, 0.64)
++-+- rate 0.125 (0, 0.585) 0.141 (0, 0.625) 0.127 (0, 0.735) 0.138 (0, 0.676) 0.132 (0, 0.651) 0.145 (0, 0.668)
++-++ graduation 0 27 18 22 25 17
++-++ futility 0 46 38 53 47 43
++-++ max_n 0 0 0 0 0 0
++-++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ post_p NA (NA, NA) NA (NA, NA) 0.47 (0.47, 0.47) 0.49 (0.46, 0.52) 0.55 (0.52, 0.58) NA (NA, NA)
++-++ rate 0.252 (0.075, 1.037) 0.226 (0.094, 1.604) 0.192 (0, 0.521) 0.133 (0, 0.46) 0.164 (0.067, 0.341) 0.145 (0.083, 0.613)
+++– graduation 0 25 19 17 20 17
+++– futility 0 37 42 46 46 37
+++– max_n 0 0 0 0 0 0
+++– n 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– n_unique 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– post_p NA (NA, NA) 0.5 (0.43, 0.56) 0.49 (0.44, 0.57) 0.5 (0.43, 0.57) 0.47 (0.42, 0.53) 0.49 (0.43, 0.59)
+++– rate 0.113 (0, 0.641) 0.14 (0, 0.534) 0.147 (0, 0.658) 0.105 (0, 0.512) 0.117 (0, 0.69) 0.109 (0, 0.838)
+++-+ graduation 0 29 22 21 26 19
+++-+ futility 0 52 53 58 59 57
+++-+ max_n 0 0 0 0 0 0
+++-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ post_p NA (NA, NA) 0.47 (0.47, 0.47) 0.51 (0.46, 0.56) 0.54 (0.54, 0.54) 0.49 (0.45, 0.54) 0.52 (0.47, 0.56)
+++-+ rate 0.213 (0, 1.686) 0.119 (0, 2.155) 0.146 (0, 0.973) 0.037 (0, 0.458) 0.119 (0, 1.68) 0.116 (0, 0.572)
++++- graduation 0 27 19 20 22 19
++++- futility 0 46 52 53 52 41
++++- max_n 0 0 0 0 0 0
++++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.55 (0.55, 0.55) 0.47 (0.47, 0.47) 0.5 (0.49, 0.52)
++++- rate 0.327 (0.049, 0.955) 0.143 (0, 0.913) 0.073 (0, 0.222) 0.122 (0, 4.585) 0.129 (0, 0.733) 0.129 (0, 0.3)
+++++ graduation 0 31 22 24 28 21
+++++ futility 0 60 62 64 64 60
+++++ max_n 0 0 0 0 0 0
+++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ post_p NA (NA, NA) 0.57 (0.57, 0.57) 0.46 (0.45, 0.52) 0.5 (0.49, 0.51) 0.47 (0.46, 0.48) NA (NA, NA)
+++++ rate 0.211 (0.053, 0.71) 0.064 (0, 1.293) 0.098 (0, 0.271) 0.111 (0, 1.173) 0.092 (0, 0.304) 0.1 (0, 0.637)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4 TC5
all count 9 7 5 4 6
all time_stop 5 (4, 6) 6 (5, 7) 7 (6, 9) 8 (7, 11) 7 (6, 8)
all n_trt 32 (28, 41) 29 (26, 34) 27 (25, 34) 42 (30, 53) 28 (25, 32)
all n_control 50 (37, 68) 64 (49, 74) 71 (61, 87) 72 (63, 96) 71 (57, 88)
all post_p 0.89 (0.87, 0.92) 0.9 (0.85, 0.96) 0.95 (0.91, 0.98) 0.96 (0.93, 0.99) 0.92 (0.87, 0.97)
all order 1 (1, 1) 1 (1, 1.4) 1 (1, 1) 1 (1, 1) 1 (1, 1)
AR- & TP53- count 35 18 16 16 10
AR- & TP53- time_stop 8 (6, 14) 10 (7, 12) 14 (10, 23) 13 (10, 24) 13 (10, 15)
AR- & TP53- n_trt 32 (27, 54) 28 (26, 41) 36 (28, 78) 38 (27, 74) 30 (25, 51)
AR- & TP53- n_control 45 (32, 72) 54 (35, 71) 76 (53, 109) 78 (55, 136) 63 (50, 97)
AR- & TP53- post_p 0.91 (0.87, 0.98) 0.94 (0.89, 0.98) 0.95 (0.89, 0.99) 0.96 (0.89, 0.98) 0.96 (0.91, 1)
AR- & TP53- order 1 (1, 1) 1 (1, 2) 1 (1, 2) 1 (1, 2) 1 (1, 2)
HRD+ count 10 7 10 13 7
HRD+ time_stop 27 (21, 30) 30 (27, 32) 22 (16, 32) 20 (17, 27) 27 (20, 33)
HRD+ n_trt 28 (26, 31) 27 (26, 30) 30 (25, 42) 27 (25, 36) 26 (25, 27)
HRD+ n_control 40 (25, 48) 44 (37, 47) 32 (24, 53) 27 (19, 35) 40 (30, 57)
HRD+ post_p 0.92 (0.88, 0.96) 0.9 (0.87, 0.96) 0.94 (0.9, 0.98) 0.95 (0.88, 0.98) 0.92 (0.87, 0.96)
HRD+ order 1 (1, 2) 1 (1, 1) 1.5 (1, 2) 1 (1, 2) 2 (1, 3)
TP53+ count 6 5 2 4 4
TP53+ time_stop 19 (14, 22) 15 (12, 18) 21 (19, 23) 14 (13, 16) 14 (10, 20)
TP53+ n_trt 28 (26, 47) 34 (25, 42) 36 (29, 44) 26 (25, 28) 28 (26, 34)
TP53+ n_control 51 (35, 68) 49 (35, 52) 64 (62, 66) 42 (39, 47) 40 (31, 54)
TP53+ post_p 0.99 (0.96, 1) 0.95 (0.9, 0.98) 0.96 (0.95, 0.97) 0.97 (0.91, 0.99) 0.96 (0.89, 0.99)
TP53+ order 1 (1, 2) 1 (1, 1.6) 1.5 (1.1, 1.9) 1.5 (1, 2) 1 (1, 1.7)
TEfus+ count 2 1 3 3 2
TEfus+ time_stop 16 (14, 17) 31 (31, 31) 19 (14, 21) 14 (12, 18) 13 (12, 14)
TEfus+ n_trt 26 (25, 26) 42 (42, 42) 31 (27, 32) 26 (25, 48) 26 (25, 26)
TEfus+ n_control 40 (40, 40) 100 (100, 100) 56 (47, 62) 38 (36, 56) 38 (36, 40)
TEfus+ post_p 0.96 (0.93, 0.99) 0.98 (0.98, 0.98) 0.95 (0.92, 0.97) 0.96 (0.95, 0.98) 0.92 (0.87, 0.97)
TEfus+ order 1 (1, 1) 3 (3, 3) 1 (1, 1.8) 2 (1.2, 2.8) 1.5 (1.1, 1.9)
PI3K+ count 6 3 5 8 2
PI3K+ time_stop 18 (13, 26) 12 (10, 13) 17 (15, 31) 16 (13, 22) 22 (20, 24)
PI3K+ n_trt 26 (25, 56) 27 (25, 29) 32 (26, 67) 26 (25, 34) 48 (46, 50)
PI3K+ n_control 58 (38, 86) 24 (21, 26) 46 (37, 101) 44 (32, 71) 66 (56, 77)
PI3K+ post_p 0.96 (0.85, 1) 0.89 (0.88, 0.97) 0.93 (0.92, 0.98) 0.93 (0.9, 0.97) 1 (0.99, 1)
PI3K+ order 1 (1, 2) 1 (1, 1) 1 (1, 2.6) 1 (1, 2.3) 1 (1, 1)
Futility:
signature var TC1 TC2 TC3 TC4 TC5
all count 5 3 2
all time_stop 4 (3, 6) 11 (7, 25) 22 (19, 24)
all n_trt 28 (27, 32) 57 (35, 115) 66 (56, 76)
all n_control 34 (28, 57) 97 (59, 229) 214 (176, 253)
all post_p 0.06 (0.03, 0.21) 0.02 (0.02, 0.03) 0.01 (0.01, 0.01)
all order 1 (1, 1) 1 (1, 2.6) 3.5 (3.1, 3.9)
AR- & TP53- count 77 61 61 53 54
AR- & TP53- time_stop 11 (6, 25) 17 (11, 28) 19 (13, 29) 17 (11, 30) 16 (10, 28)
AR- & TP53- n_trt 36 (26, 59) 37 (26, 58) 38 (26, 69) 37 (25, 71) 38 (25, 65)
AR- & TP53- n_control 59 (31, 142) 92 (60, 175) 96 (68, 169) 90 (57, 179) 90 (51, 164)
AR- & TP53- post_p 0.13 (0.03, 0.26) 0.11 (0.02, 0.25) 0.12 (0.02, 0.24) 0.07 (0.01, 0.18) 0.09 (0.02, 0.24)
AR- & TP53- order 1 (1, 2) 1 (1, 3) 1 (1, 3) 1 (1, 2) 1 (1, 3)
HRD+ count 12 9 31 23 10
HRD+ time_stop 30 (23, 35) 35 (27, 36) 30 (24, 34) 29 (20, 35) 29 (24, 35)
HRD+ n_trt 25 (25, 29) 26 (26, 28) 29 (25, 34) 27 (25, 34) 26 (25, 30)
HRD+ n_control 42 (36, 65) 52 (36, 71) 49 (32, 63) 43 (30, 58) 44 (38, 50)
HRD+ post_p 0.09 (0.02, 0.27) 0.15 (0.09, 0.28) 0.15 (0.06, 0.26) 0.15 (0.03, 0.22) 0.15 (0.06, 0.18)
HRD+ order 2 (1, 3) 3 (2, 5.2) 2 (1, 3) 2 (1, 4) 2 (1, 3.1)
TP53+ count 20 33 18 24 28
TP53+ time_stop 22 (15, 30) 19 (13, 28) 24 (17, 32) 25 (18, 35) 18 (13, 32)
TP53+ n_trt 30 (26, 43) 29 (26, 44) 31 (25, 42) 34 (25, 51) 30 (25, 49)
TP53+ n_control 60 (42, 93) 54 (36, 96) 76 (48, 101) 81 (48, 124) 60 (32, 105)
TP53+ post_p 0.08 (0.02, 0.21) 0.09 (0.03, 0.23) 0.07 (0.01, 0.17) 0.08 (0.04, 0.13) 0.07 (0.01, 0.23)
TP53+ order 1 (1, 2) 1 (1, 2) 1 (1, 3) 2 (1, 3) 2 (1, 2.3)
TEfus+ count 11 14 9 11 9
TEfus+ time_stop 21 (17, 33) 19 (12, 33) 22 (19, 33) 24 (18, 34) 23 (16, 32)
TEfus+ n_trt 27 (25, 33) 29 (25, 40) 30 (26, 44) 29 (25, 43) 33 (26, 46)
TEfus+ n_control 55 (30, 112) 64 (27, 109) 74 (37, 99) 68 (49, 99) 54 (44, 98)
TEfus+ post_p 0.08 (0.04, 0.26) 0.03 (0.01, 0.19) 0.12 (0.06, 0.23) 0.02 (0, 0.06) 0.02 (0, 0.06)
TEfus+ order 2 (1, 3) 2 (1, 3) 2 (2, 3.4) 3 (1, 5) 2 (1, 5)
PI3K+ count 22 20 15 18 29
PI3K+ time_stop 24 (16, 32) 20 (14, 31) 23 (19, 29) 24 (17, 31) 16 (10, 28)
PI3K+ n_trt 32 (26, 42) 31 (25, 44) 31 (27, 40) 29 (25, 48) 31 (25, 47)
PI3K+ n_control 68 (44, 120) 68 (30, 96) 62 (47, 88) 74 (50, 102) 45 (30, 85)
PI3K+ post_p 0.12 (0.02, 0.21) 0.09 (0.03, 0.16) 0.08 (0.03, 0.17) 0.07 (0.01, 0.24) 0.11 (0.02, 0.29)
PI3K+ order 2 (1, 3) 2 (1, 4) 2 (1, 3.6) 2 (1, 3) 1 (1, 3)


By subgroup combinations

Graduation:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9
all TC1 time 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6)
all TC1 n 18 (15, 24) 2 (1, 5) 1 (0, 3) 1 (0, 2) 3 (2, 5) 1 (0, 2) 0 (0, 1) 0 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 1 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 2) 1 (0, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.6 (0.55, 0.68) 0.54 (0.5, 0.7) 0.54 (0.52, 0.57) 0.53 (0.51, 0.56) 0.56 (0.54, 0.59) 0.54 (0.52, 0.56) 0.54 (0.51, 0.56) 0.53 (0.52, 0.57) 0.52 (0.51, 0.54) NA (NA, NA) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.54 (0.51, 0.57) NA (NA, NA) 0.52 (0.51, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.56 (0.54, 0.6) 0.52 (0.52, 0.6) 0.57 (0.57, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.072 (0.038, 0.105) 0 (0, 0.089) 0 (0, 0.372) 0 (0, 0.246) 0 (0, 0.084) 0 (0, 0.074) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 1.536) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0.09) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 count 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
all TC2 time 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7)
all TC2 n 11 (6, 14) 1 (0, 2) 0 (0, 1) 0 (0, 0) 3 (2, 5) 2 (0, 2) 1 (0, 5) 2 (0, 2) 0 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 2) 1 (0, 1) 0 (0, 1) 0 (0, 0) 4 (2, 5) 1 (0, 3) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.62 (0.54, 0.67) 0.52 (0.51, 0.52) 0.52 (0.52, 0.52) 0.54 (0.54, 0.54) 0.55 (0.53, 0.61) 0.56 (0.53, 0.65) 0.55 (0.52, 0.57) 0.6 (0.53, 0.6) 0.53 (0.52, 0.55) NA (NA, NA) 0.76 (0.76, 0.76) 0.56 (0.56, 0.56) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) 0.57 (0.57, 0.58) NA (NA, NA) 0.54 (0.52, 0.59) 0.5 (0.5, 0.5) 0.56 (0.56, 0.56) NA (NA, NA) 0.56 (0.52, 0.65) 0.55 (0.54, 0.55) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.069 (0.033, 0.114) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.063) 0 (0, 0) 0 (0, 0.151) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 2.626) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.378 (0.378, 0.378) 0.063 (0.013, 0.113) 0 (0, 0) 0 (0, 0.043) 0 (0, 0.684) 0.386 (0.077, 0.695) NA (NA, NA) 0 (0, 0.048) 0.026 (0, 0.122) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
all TC3 time 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9)
all TC3 n 5 (3, 6) 2 (0, 4) 0 (0, 1) 1 (0, 2) 2 (1, 4) 1 (0, 2) 0 (0, 1) 2 (0, 4) 3 (2, 6) 0 (0, 0) 1 (0, 2) 1 (0, 3) 0 (0, 0) 0 (0, 2) 0 (0, 0) 1 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 2 (0, 4) 3 (1, 6) 2 (0, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.6 (0.56, 0.67) 0.53 (0.52, 0.76) 0.58 (0.58, 0.58) 0.57 (0.55, 0.59) 0.52 (0.51, 0.6) 0.61 (0.6, 0.61) 0.53 (0.52, 0.54) 0.55 (0.52, 0.75) 0.56 (0.54, 0.7) NA (NA, NA) 0.53 (0.51, 0.54) 0.53 (0.51, 0.55) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) 0.53 (0.52, 0.54) 0.57 (0.57, 0.57) NA (NA, NA) 0.57 (0.57, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.56 (0.52, 0.58) 0.56 (0.53, 0.72) 0.6 (0.54, 0.64) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC3 rate 0.075 (0, 0.092) 0 (0, 0.059) 0 (0, 0) 0 (0, 0) 0 (0, 0.093) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.092 (0, 0.107) NA (NA, NA) 0 (0, 0) 0 (0, 0.14) NA (NA, NA) 0.091 (0.018, 0.164) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0.1) 0 (0, 0.072) 0 (0, 0.074) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC4 time 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11)
all TC4 n 6 (5, 10) 6 (3, 7) 0 (0, 1) 0 (0, 2) 2 (0, 5) 4 (2, 4) 1 (0, 2) 2 (1, 7) 6 (4, 8) 0 (0, 0) 4 (3, 4) 0 (0, 2) 0 (0, 0) 2 (0, 2) 0 (0, 0) 2 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 1 (0, 3) 0 (0, 2) 1 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.66 (0.54, 0.72) 0.62 (0.58, 0.78) 0.6 (0.6, 0.6) 0.61 (0.61, 0.61) 0.66 (0.55, 0.72) 0.65 (0.58, 0.73) 0.59 (0.58, 0.6) 0.58 (0.53, 0.62) 0.74 (0.59, 0.83) NA (NA, NA) 0.59 (0.55, 0.67) 0.61 (0.61, 0.61) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.54 (0.52, 0.56) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.68 (0.55, 0.69) 0.59 (0.55, 0.63) 0.54 (0.53, 0.55) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC4 rate 0.05 (0, 0.106) 0.069 (0.012, 0.111) 0 (0, 0) 0.082 (0.082, 0.082) 0 (0, 0.077) 0 (0, 0.042) 0 (0, 0) 0 (0, 0.032) 0.048 (0.034, 0.062) NA (NA, NA) 0.031 (0, 0.079) 0 (0, 0) NA (NA, NA) 0.111 (0.022, 0.292) NA (NA, NA) 0.167 (0.033, 0.186) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.388 (0.388, 0.388) NA (NA, NA) 0 (0, 0.09) 0 (0, 0) 0 (0, 0.093) NA (NA, NA) 0.596 (0.119, 1.073) 1.728 (1.728, 1.728) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
all TC5 time 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8)
all TC5 n 4 (3, 6) 6 (2, 8) 0 (0, 0) 2 (0, 4) 2 (0, 4) 4 (2, 7) 0 (0, 0) 3 (2, 5) 0 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 0) 1 (0, 2) 3 (2, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 post_p 0.59 (0.56, 0.67) 0.54 (0.52, 0.64) NA (NA, NA) 0.56 (0.56, 0.6) 0.53 (0.52, 0.55) 0.6 (0.58, 0.63) 0.51 (0.51, 0.51) 0.56 (0.52, 0.78) 0.53 (0.52, 0.56) NA (NA, NA) 0.55 (0.54, 0.56) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) 0.57 (0.56, 0.58) 0.58 (0.57, 0.64) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0 (0, 0.085) 0.057 (0, 0.092) NA (NA, NA) 0 (0, 0.061) 0.138 (0.039, 0.306) 0.024 (0, 0.063) 0 (0, 0) 0.019 (0, 0.13) 0 (0, 0.155) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.025 (0, 0.128) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 35 35 35 35 35 35 35 35
AR- & TP53- TC1 time 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14)
AR- & TP53- TC1 n 25 (20, 39) 3 (0, 6) 1 (0, 2) 2 (0, 5) 1 (0, 4) 0 (0, 0) 1 (0, 2) 0 (0, 1)
AR- & TP53- TC1 post_p 0.84 (0.74, 0.93) 0.61 (0.52, 0.78) 0.53 (0.5, 0.62) 0.53 (0.51, 0.7) 0.55 (0.51, 0.67) NA (NA, NA) 0.55 (0.51, 0.61) 0.55 (0.53, 0.62)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.071 (0.041, 0.097) 0.018 (0, 0.105) 0 (0, 0.29) 0.054 (0, 0.162) 0 (0, 0.102) NA (NA, NA) 0 (0, 0.01) 0 (0, 0)
AR- & TP53- TC2 count 18 18 18 18 18 18 18 18
AR- & TP53- TC2 time 10 (7, 12) 10 (7, 12) 10 (7, 12) 10 (7, 12) 10 (7, 12) 10 (7, 12) 10 (7, 12) 10 (7, 12)
AR- & TP53- TC2 n 21 (16, 26) 3 (1, 6) 1 (0, 2) 1 (0, 2) 2 (1, 4) 0 (0, 0) 1 (0, 2) 0 (0, 2)
AR- & TP53- TC2 post_p 0.83 (0.73, 0.95) 0.61 (0.53, 0.8) 0.53 (0.52, 0.57) 0.52 (0.51, 0.65) 0.63 (0.54, 0.74) NA (NA, NA) 0.55 (0.51, 0.64) 0.55 (0.53, 0.61)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.072 (0.03, 0.095) 0 (0, 0.099) 0 (0, 0.208) 0 (0, 0.065) 0 (0, 0.051) 0 (0, 0) 0 (0, 0.205) 0 (0, 0)
AR- & TP53- TC3 count 16 16 16 16 16 16 16 16
AR- & TP53- TC3 time 14 (10, 23) 14 (10, 23) 14 (10, 23) 14 (10, 23) 14 (10, 23) 14 (10, 23) 14 (10, 23) 14 (10, 23)
AR- & TP53- TC3 n 15 (12, 46) 4 (2, 10) 0 (0, 2) 2 (0, 5) 6 (4, 18) 0 (0, 0) 4 (2, 6) 1 (0, 4)
AR- & TP53- TC3 post_p 0.76 (0.71, 0.92) 0.59 (0.52, 0.78) 0.66 (0.56, 0.8) 0.59 (0.54, 0.79) 0.75 (0.61, 0.89) NA (NA, NA) 0.57 (0.52, 0.77) 0.57 (0.53, 0.7)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.067 (0.036, 0.097) 0.076 (0, 0.125) 0 (0, 0.069) 0.032 (0, 0.118) 0.064 (0.028, 0.078) NA (NA, NA) 0.072 (0, 0.101) 0.02 (0, 0.157)
AR- & TP53- TC4 count 16 16 16 16 16 16 16 16
AR- & TP53- TC4 time 13 (10, 24) 13 (10, 24) 13 (10, 24) 13 (10, 24) 13 (10, 24) 13 (10, 24) 13 (10, 24) 13 (10, 24)
AR- & TP53- TC4 n 21 (15, 40) 4 (1, 10) 0 (0, 2) 1 (0, 4) 8 (3, 14) 0 (0, 0) 3 (1, 4) 0 (0, 2)
AR- & TP53- TC4 post_p 0.79 (0.72, 0.91) 0.73 (0.58, 0.81) 0.56 (0.52, 0.58) 0.61 (0.54, 0.83) 0.78 (0.52, 0.9) 0.62 (0.62, 0.62) 0.55 (0.52, 0.59) 0.56 (0.53, 0.64)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.081 (0.038, 0.103) 0 (0, 0.08) 0.023 (0, 0.634) 0 (0, 0.063) 0.067 (0.011, 0.082) 0 (0, 0) 0.086 (0.01, 0.142) 0.052 (0, 1.491)
AR- & TP53- TC5 count 10 10 10 10 10 10 10 10
AR- & TP53- TC5 time 13 (10, 15) 13 (10, 15) 13 (10, 15) 13 (10, 15) 13 (10, 15) 13 (10, 15) 13 (10, 15) 13 (10, 15)
AR- & TP53- TC5 n 18 (12, 22) 8 (4, 12) 0 (0, 2) 2 (0, 6) 2 (0, 3) 0 (0, 0) 4 (0, 4) 1 (0, 2)
AR- & TP53- TC5 post_p 0.8 (0.77, 0.95) 0.79 (0.73, 0.93) 0.55 (0.53, 0.68) 0.54 (0.51, 0.77) 0.64 (0.59, 0.67) NA (NA, NA) 0.64 (0.53, 0.7) 0.61 (0.58, 0.67)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.061 (0.036, 0.106) 0.053 (0.023, 0.082) 0 (0, 0.187) 0.06 (0, 0.125) 0 (0, 0.014) 0 (0, 0) 0 (0, 0.087) 0 (0, 0.062)
HRD+ TC1 count 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
HRD+ TC1 time 27 (21, 30) 27 (21, 30) 27 (21, 30) 27 (21, 30) 27 (21, 30) 27 (21, 30) 27 (21, 30) 27 (21, 30) 27 (21, 30) 27 (21, 30) 27 (21, 30) 27 (21, 30) 27 (21, 30) 27 (21, 30) 27 (21, 30) 27 (21, 30)
HRD+ TC1 n 15 (10, 20) 0 (0, 0) 4 (3, 6) 2 (0, 4) 0 (0, 0) 2 (0, 3) 0 (0, 0) 2 (0, 2) 4 (0, 8) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.83 (0.73, 0.92) NA (NA, NA) 0.69 (0.54, 0.81) 0.56 (0.5, 0.63) NA (NA, NA) 0.65 (0.58, 0.71) NA (NA, NA) 0.62 (0.53, 0.79) 0.79 (0.51, 0.91) NA (NA, NA) 0.53 (0.53, 0.61) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.091 (0.07, 0.094) NA (NA, NA) 0.072 (0.063, 0.115) 0.084 (0.043, 0.224) NA (NA, NA) 0.085 (0.055, 0.116) NA (NA, NA) 0.056 (0, 0.195) 0.046 (0.015, 0.119) NA (NA, NA) 0.138 (0, 0.187) NA (NA, NA) NA (NA, NA) 0.147 (0.147, 0.147) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
HRD+ TC2 time 30 (27, 32) 30 (27, 32) 30 (27, 32) 30 (27, 32) 30 (27, 32) 30 (27, 32) 30 (27, 32) 30 (27, 32) 30 (27, 32) 30 (27, 32) 30 (27, 32) 30 (27, 32) 30 (27, 32) 30 (27, 32) 30 (27, 32) 30 (27, 32)
HRD+ TC2 n 14 (7, 18) 0 (0, 0) 4 (0, 12) 2 (1, 4) 0 (0, 0) 0 (0, 3) 0 (0, 0) 0 (0, 2) 3 (1, 6) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1)
HRD+ TC2 post_p 0.78 (0.75, 0.93) NA (NA, NA) 0.72 (0.56, 0.87) 0.62 (0.52, 0.69) NA (NA, NA) 0.55 (0.51, 0.58) NA (NA, NA) 0.54 (0.53, 0.64) 0.63 (0.56, 0.77) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.091 (0.075, 0.103) NA (NA, NA) 0.085 (0.067, 0.155) 0.036 (0, 0.108) NA (NA, NA) 0.126 (0.095, 0.157) NA (NA, NA) 0.05 (0.01, 0.075) 0.096 (0.033, 0.147) NA (NA, NA) 0.058 (0.012, 0.104) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0.135 (0.027, 0.244)
HRD+ TC3 count 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
HRD+ TC3 time 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32)
HRD+ TC3 n 14 (12, 25) 0 (0, 0) 7 (4, 12) 2 (0, 3) 0 (0, 0) 1 (0, 3) 0 (0, 0) 2 (0, 4) 3 (3, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.86 (0.74, 0.93) NA (NA, NA) 0.75 (0.54, 0.95) 0.65 (0.53, 0.81) 0.51 (0.51, 0.51) 0.51 (0.5, 0.58) NA (NA, NA) 0.57 (0.54, 0.58) 0.66 (0.54, 0.87) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.075 (0.061, 0.088) 3.688 (3.688, 3.688) 0.068 (0.048, 0.106) 0.097 (0, 0.173) 0.186 (0.186, 0.186) 0.106 (0.071, 0.522) NA (NA, NA) 0.112 (0, 0.193) 0.065 (0.027, 0.178) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.398 (0.398, 0.398) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC4 count 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13
HRD+ TC4 time 20 (17, 27) 20 (17, 27) 20 (17, 27) 20 (17, 27) 20 (17, 27) 20 (17, 27) 20 (17, 27) 20 (17, 27) 20 (17, 27) 20 (17, 27) 20 (17, 27) 20 (17, 27) 20 (17, 27) 20 (17, 27) 20 (17, 27) 20 (17, 27)
HRD+ TC4 n 13 (9, 16) 0 (0, 0) 5 (3, 13) 2 (1, 4) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (1, 3) 4 (1, 4) 0 (0, 0) 0 (0, 3) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.85 (0.75, 0.91) NA (NA, NA) 0.68 (0.52, 0.89) 0.53 (0.51, 0.62) NA (NA, NA) 0.56 (0.55, 0.77) NA (NA, NA) 0.56 (0.52, 0.63) 0.54 (0.5, 0.65) NA (NA, NA) 0.71 (0.71, 0.71) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.08 (0.043, 0.093) 0 (0, 0) 0.06 (0.034, 0.098) 0.088 (0.006, 0.25) NA (NA, NA) 0.052 (0, 0.118) NA (NA, NA) 0.091 (0.003, 0.23) 0.073 (0.003, 0.16) 0 (0, 0) 0.089 (0.039, 0.272) NA (NA, NA) 0.066 (0, 0.392) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 count 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
HRD+ TC5 time 27 (20, 33) 27 (20, 33) 27 (20, 33) 27 (20, 33) 27 (20, 33) 27 (20, 33) 27 (20, 33) 27 (20, 33) 27 (20, 33) 27 (20, 33) 27 (20, 33) 27 (20, 33) 27 (20, 33) 27 (20, 33) 27 (20, 33) 27 (20, 33)
HRD+ TC5 n 14 (9, 16) 0 (0, 0) 5 (3, 9) 2 (1, 4) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 2) 3 (2, 5) 0 (0, 0) 1 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0)
HRD+ TC5 post_p 0.78 (0.67, 0.89) NA (NA, NA) 0.64 (0.57, 0.88) 0.53 (0.51, 0.73) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.58 (0.52, 0.63) 0.64 (0.52, 0.77) NA (NA, NA) 0.59 (0.58, 0.59) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 rate 0.093 (0.065, 0.113) NA (NA, NA) 0.06 (0.032, 0.105) 0.086 (0.033, 0.184) NA (NA, NA) 0.125 (0.067, 0.182) NA (NA, NA) 0.116 (0.023, 0.172) 0.09 (0.037, 0.109) NA (NA, NA) 0 (0, 0.062) 0 (0, 0) NA (NA, NA) 0.302 (0.06, 0.543) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
TP53+ TC1 time 19 (14, 22) 19 (14, 22) 19 (14, 22) 19 (14, 22) 19 (14, 22) 19 (14, 22) 19 (14, 22) 19 (14, 22) 19 (14, 22) 19 (14, 22) 19 (14, 22) 19 (14, 22) 19 (14, 22) 19 (14, 22) 19 (14, 22) 19 (14, 22)
TP53+ TC1 n 8 (6, 12) 6 (4, 10) 2 (2, 4) 4 (2, 8) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 4 (1, 8) 5 (3, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.78 (0.7, 0.91) 0.72 (0.6, 0.83) 0.61 (0.51, 0.71) 0.64 (0.57, 0.81) NA (NA, NA) 0.51 (0.5, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.62 (0.59, 0.75) 0.77 (0.62, 0.9) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.064 (0.042, 0.082) 0.069 (0.017, 0.128) 0.083 (0, 0.165) 0.027 (0, 0.09) NA (NA, NA) 0.126 (0.081, 0.171) NA (NA, NA) 0 (0, 0) 0.593 (0.593, 0.593) NA (NA, NA) 0.088 (0.023, 0.112) 0.061 (0.014, 0.091) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
TP53+ TC2 time 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18) 15 (12, 18)
TP53+ TC2 n 7 (5, 10) 7 (3, 11) 2 (1, 5) 3 (2, 8) 0 (0, 1) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 5 (5, 6) 5 (4, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.79 (0.52, 0.83) 0.72 (0.6, 0.89) 0.57 (0.52, 0.69) 0.67 (0.57, 0.72) NA (NA, NA) 0.54 (0.52, 0.56) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) 0.65 (0.55, 0.79) 0.76 (0.57, 0.82) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.095 (0.077, 0.126) 0.037 (0.011, 0.089) 0.077 (0, 0.138) 0.044 (0, 0.091) 0 (0, 0) 0.033 (0.007, 0.059) NA (NA, NA) 0 (0, 0) 0.114 (0.114, 0.114) NA (NA, NA) 0.081 (0.056, 0.119) 0.06 (0.03, 0.112) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
TP53+ TC3 time 21 (19, 23) 21 (19, 23) 21 (19, 23) 21 (19, 23) 21 (19, 23) 21 (19, 23) 21 (19, 23) 21 (19, 23) 21 (19, 23) 21 (19, 23) 21 (19, 23) 21 (19, 23) 21 (19, 23) 21 (19, 23) 21 (19, 23) 21 (19, 23)
TP53+ TC3 n 10 (5, 14) 10 (7, 13) 2 (1, 2) 3 (1, 5) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 8 (5, 10) 4 (4, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.7 (0.63, 0.77) 0.74 (0.73, 0.74) 0.52 (0.52, 0.52) 0.74 (0.65, 0.83) NA (NA, NA) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.69 (0.58, 0.8) 0.76 (0.74, 0.78) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.077 (0.072, 0.082) 0.064 (0.057, 0.071) 0.08 (0.016, 0.144) 0.02 (0.004, 0.036) NA (NA, NA) 0.118 (0.118, 0.118) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.096 (0.082, 0.109) 0.061 (0.057, 0.065) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
TP53+ TC4 time 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16) 14 (13, 16)
TP53+ TC4 n 5 (3, 7) 4 (2, 9) 3 (1, 5) 2 (0, 7) 0 (0, 0) 0 (0, 1) 0 (0, 0) 1 (0, 2) 0 (0, 1) 0 (0, 0) 5 (4, 6) 4 (1, 5) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.74 (0.57, 0.77) 0.72 (0.64, 0.76) 0.61 (0.6, 0.72) 0.68 (0.64, 0.71) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.56 (0.56, 0.56) NA (NA, NA) NA (NA, NA) 0.77 (0.74, 0.82) 0.68 (0.6, 0.69) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.076 (0.042, 0.141) 0.015 (0, 0.062) 0 (0, 0.025) 0.053 (0.038, 0.069) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.11 (0.064, 0.155) 0.271 (0.054, 0.487) NA (NA, NA) 0.055 (0.044, 0.088) 0.06 (0.042, 0.068) 0.321 (0.321, 0.321) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
TP53+ TC5 time 14 (10, 20) 14 (10, 20) 14 (10, 20) 14 (10, 20) 14 (10, 20) 14 (10, 20) 14 (10, 20) 14 (10, 20) 14 (10, 20) 14 (10, 20) 14 (10, 20) 14 (10, 20) 14 (10, 20) 14 (10, 20) 14 (10, 20) 14 (10, 20)
TP53+ TC5 n 5 (5, 5) 7 (6, 8) 1 (0, 2) 6 (4, 10) 0 (0, 0) 2 (1, 2) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 2 (1, 8) 4 (2, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.63 (0.55, 0.7) 0.78 (0.7, 0.85) 0.52 (0.5, 0.54) 0.72 (0.6, 0.9) NA (NA, NA) 0.53 (0.52, 0.58) NA (NA, NA) 0.53 (0.53, 0.53) 0.5 (0.5, 0.5) NA (NA, NA) 0.61 (0.55, 0.76) 0.6 (0.53, 0.68) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.095 (0.07, 0.134) 0.056 (0.009, 0.088) 0.098 (0.078, 0.117) 0.04 (0.007, 0.081) NA (NA, NA) 0.044 (0, 0.598) NA (NA, NA) 0 (0, 0) 0.14 (0.14, 0.14) NA (NA, NA) 0.07 (0.012, 0.128) 0.083 (0.021, 0.121) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
TEfus+ TC1 time 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17)
TEfus+ TC1 n 2 (1, 4) 0 (0, 0) 0 (0, 1) 5 (4, 6) 3 (1, 5) 2 (1, 2) 0 (0, 0) 1 (0, 2) 4 (3, 4) 1 (1, 1) 6 (5, 6) 2 (1, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.59 (0.56, 0.61) NA (NA, NA) 0.55 (0.55, 0.55) 0.8 (0.74, 0.86) 0.56 (0.56, 0.56) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) 0.62 (0.55, 0.7) 0.58 (0.58, 0.58) 0.72 (0.62, 0.81) 0.68 (0.64, 0.72) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.038 (0.008, 0.068) NA (NA, NA) 0 (0, 0) 0.037 (0.026, 0.047) 0.048 (0.01, 0.087) 0.793 (0.159, 1.427) NA (NA, NA) 0.358 (0.358, 0.358) 0.069 (0.014, 0.125) 0 (0, 0) 0.071 (0.041, 0.1) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TEfus+ TC2 time 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31)
TEfus+ TC2 n 2 (2, 2) 3 (3, 3) 1 (1, 1) 11 (11, 11) 0 (0, 0) 3 (3, 3) 0 (0, 0) 1 (1, 1) 6 (6, 6) 4 (4, 4) 5 (5, 5) 6 (6, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.6 (0.6, 0.6) 0.51 (0.51, 0.51) 0.53 (0.53, 0.53) 0.92 (0.92, 0.92) NA (NA, NA) 0.56 (0.56, 0.56) NA (NA, NA) 0.52 (0.52, 0.52) 0.87 (0.87, 0.87) 0.58 (0.58, 0.58) 0.52 (0.52, 0.52) 0.95 (0.95, 0.95) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.092 (0.092, 0.092) 0.085 (0.085, 0.085) 0.154 (0.154, 0.154) 0.069 (0.069, 0.069) NA (NA, NA) 0.084 (0.084, 0.084) NA (NA, NA) 0.077 (0.077, 0.077) 0.089 (0.089, 0.089) 0.074 (0.074, 0.074) 0.106 (0.106, 0.106) 0.034 (0.034, 0.034) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TEfus+ TC3 time 19 (14, 21) 19 (14, 21) 19 (14, 21) 19 (14, 21) 19 (14, 21) 19 (14, 21) 19 (14, 21) 19 (14, 21) 19 (14, 21) 19 (14, 21) 19 (14, 21) 19 (14, 21) 19 (14, 21) 19 (14, 21) 19 (14, 21) 19 (14, 21)
TEfus+ TC3 n 0 (0, 0) 3 (1, 4) 2 (1, 4) 5 (3, 5) 5 (5, 7) 2 (0, 3) 0 (0, 0) 1 (0, 2) 2 (2, 3) 1 (0, 2) 4 (3, 6) 4 (3, 5) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p NA (NA, NA) 0.76 (0.61, 0.76) 0.54 (0.51, 0.57) 0.69 (0.59, 0.86) 0.64 (0.59, 0.73) 0.55 (0.54, 0.57) NA (NA, NA) NA (NA, NA) 0.58 (0.57, 0.65) 0.51 (0.51, 0.51) 0.65 (0.59, 0.7) 0.63 (0.55, 0.74) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC3 rate NA (NA, NA) 0.033 (0.007, 0.044) 0.058 (0.012, 0.062) 0.053 (0.011, 0.091) 0.087 (0.08, 0.106) 0.087 (0.068, 0.107) NA (NA, NA) 0.138 (0.028, 0.248) 0 (0, 0.032) 0.145 (0.029, 0.26) 0.055 (0.049, 0.067) 0.057 (0.011, 0.096) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TEfus+ TC4 time 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18)
TEfus+ TC4 n 4 (1, 5) 3 (1, 3) 2 (2, 2) 8 (5, 9) 3 (2, 4) 2 (0, 7) 0 (0, 0) 2 (1, 3) 2 (0, 4) 1 (0, 3) 4 (2, 10) 2 (0, 6) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.56 (0.56, 0.56) 0.63 (0.56, 0.7) 0.6 (0.56, 0.73) 0.72 (0.64, 0.72) 0.58 (0.54, 0.69) 0.67 (0.6, 0.74) NA (NA, NA) 0.54 (0.53, 0.55) 0.53 (0.51, 0.56) 0.81 (0.81, 0.81) 0.74 (0.59, 0.87) 0.66 (0.56, 0.76) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.081 (0.076, 0.085) 0.097 (0.081, 0.113) 0 (0, 0.058) 0.034 (0.007, 0.052) 0.116 (0.065, 0.129) 0.038 (0.008, 0.069) NA (NA, NA) 0.167 (0.033, 0.212) 0.121 (0.024, 0.217) 0.027 (0.005, 0.049) 0.101 (0.075, 0.114) 0.073 (0.052, 0.093) NA (NA, NA) 1.728 (1.728, 1.728) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
TEfus+ TC5 time 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14) 13 (12, 14)
TEfus+ TC5 n 0 (0, 1) 4 (4, 5) 1 (0, 2) 4 (3, 5) 2 (0, 3) 0 (0, 1) 0 (0, 0) 0 (0, 1) 2 (1, 4) 2 (0, 3) 4 (3, 4) 4 (4, 5) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p NA (NA, NA) 0.65 (0.61, 0.69) 0.51 (0.51, 0.51) 0.68 (0.66, 0.7) 0.74 (0.74, 0.74) NA (NA, NA) NA (NA, NA) 0.54 (0.54, 0.54) 0.7 (0.58, 0.83) NA (NA, NA) 0.51 (0.5, 0.51) 0.62 (0.57, 0.68) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 0 (0, 0) 0.067 (0.049, 0.086) 0.114 (0.114, 0.114) 0.042 (0.036, 0.047) 0 (0, 0) 0.159 (0.159, 0.159) NA (NA, NA) 0 (0, 0) 0.025 (0.005, 0.046) 0.062 (0.062, 0.062) 0.117 (0.114, 0.12) 0.063 (0.062, 0.064) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
PI3K+ TC1 time 18 (13, 26) 18 (13, 26) 18 (13, 26) 18 (13, 26) 18 (13, 26) 18 (13, 26) 18 (13, 26) 18 (13, 26) 18 (13, 26) 18 (13, 26) 18 (13, 26) 18 (13, 26) 18 (13, 26) 18 (13, 26) 18 (13, 26) 18 (13, 26)
PI3K+ TC1 n 8 (4, 18) 4 (2, 8) 6 (4, 13) 3 (2, 4) 0 (0, 0) 0 (0, 2) 0 (0, 3) 0 (0, 0) 0 (0, 2) 2 (0, 3) 0 (0, 0) 4 (2, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.88 (0.72, 0.95) 0.62 (0.51, 0.76) 0.73 (0.56, 0.9) 0.57 (0.51, 0.76) NA (NA, NA) 0.72 (0.72, 0.72) 0.57 (0.53, 0.61) NA (NA, NA) NA (NA, NA) 0.55 (0.51, 0.63) NA (NA, NA) 0.6 (0.53, 0.75) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.067 (0.05, 0.09) 0.104 (0.081, 0.158) 0.074 (0.036, 0.1) 0.091 (0.041, 0.12) NA (NA, NA) 0.14 (0.14, 0.14) 0 (0, 0.083) 0 (0, 0) 0.149 (0.03, 0.267) 0.063 (0, 0.137) NA (NA, NA) 0.071 (0.029, 0.127) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
PI3K+ TC2 time 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13)
PI3K+ TC2 n 7 (5, 7) 2 (2, 3) 3 (2, 8) 3 (3, 5) 0 (0, 0) 1 (1, 3) 0 (0, 1) 1 (1, 1) 1 (0, 3) 2 (1, 4) 0 (0, 0) 4 (2, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.75 (0.72, 0.76) 0.59 (0.54, 0.66) 0.62 (0.61, 0.8) 0.63 (0.57, 0.69) NA (NA, NA) 0.54 (0.54, 0.54) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA) 0.59 (0.53, 0.66) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.034 (0.007, 0.037) 0 (0, 0) 0 (0, 0) 0.067 (0.038, 0.234) NA (NA, NA) 0 (0, 0.087) 0 (0, 0) 0 (0, 0) 0.018 (0.004, 0.033) 0.038 (0.008, 0.199) NA (NA, NA) 0.076 (0.015, 0.107) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
PI3K+ TC3 time 17 (15, 31) 17 (15, 31) 17 (15, 31) 17 (15, 31) 17 (15, 31) 17 (15, 31) 17 (15, 31) 17 (15, 31) 17 (15, 31) 17 (15, 31) 17 (15, 31) 17 (15, 31) 17 (15, 31) 17 (15, 31) 17 (15, 31) 17 (15, 31)
PI3K+ TC3 n 9 (6, 21) 4 (1, 10) 10 (4, 14) 4 (2, 11) 0 (0, 0) 1 (0, 3) 0 (0, 1) 1 (0, 3) 0 (0, 1) 0 (0, 3) 0 (0, 1) 4 (0, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.79 (0.74, 0.85) 0.57 (0.55, 0.75) 0.7 (0.57, 0.76) 0.64 (0.56, 0.9) NA (NA, NA) 0.63 (0.6, 0.81) 0.5 (0.5, 0.5) 0.54 (0.51, 0.57) 0.53 (0.53, 0.54) 0.56 (0.56, 0.56) NA (NA, NA) 0.58 (0.53, 0.75) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.07 (0.055, 0.091) 0.096 (0.029, 0.113) 0.084 (0.061, 0.106) 0.048 (0, 0.086) NA (NA, NA) 0 (0, 0.023) 0.098 (0.02, 0.176) 0.072 (0.069, 0.099) 0.133 (0.027, 0.24) 0 (0, 0) 1.04 (1.04, 1.04) 0.073 (0.01, 0.133) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 count 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
PI3K+ TC4 time 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22)
PI3K+ TC4 n 4 (3, 10) 2 (1, 3) 8 (3, 10) 4 (1, 7) 0 (0, 1) 2 (1, 2) 1 (0, 2) 1 (1, 2) 0 (0, 2) 0 (0, 1) 0 (0, 0) 4 (1, 6) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC4 post_p 0.67 (0.56, 0.85) 0.56 (0.53, 0.64) 0.73 (0.57, 0.81) 0.63 (0.51, 0.72) 0.54 (0.54, 0.54) 0.56 (0.52, 0.58) 0.52 (0.51, 0.67) 0.57 (0.52, 0.58) NA (NA, NA) 0.57 (0.52, 0.77) NA (NA, NA) 0.55 (0.51, 0.67) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.064 (0.045, 0.09) 0 (0, 0.114) 0.069 (0.021, 0.084) 0.087 (0.052, 0.136) 0.487 (0.18, 0.795) 0.127 (0, 0.192) 0.038 (0, 0.049) 0 (0, 0.064) 0 (0, 0.082) 0 (0, 0.101) NA (NA, NA) 0.103 (0.058, 0.128) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
PI3K+ TC5 time 22 (20, 24) 22 (20, 24) 22 (20, 24) 22 (20, 24) 22 (20, 24) 22 (20, 24) 22 (20, 24) 22 (20, 24) 22 (20, 24) 22 (20, 24) 22 (20, 24) 22 (20, 24) 22 (20, 24) 22 (20, 24) 22 (20, 24) 22 (20, 24)
PI3K+ TC5 n 11 (10, 12) 4 (4, 5) 11 (9, 13) 7 (5, 9) 0 (0, 0) 1 (0, 2) 0 (0, 1) 0 (0, 0) 1 (0, 2) 2 (2, 3) 0 (0, 0) 10 (8, 12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 post_p 0.81 (0.74, 0.88) 0.65 (0.56, 0.74) 0.76 (0.72, 0.8) 0.66 (0.6, 0.71) NA (NA, NA) 0.56 (0.56, 0.56) 0.61 (0.61, 0.61) NA (NA, NA) 0.58 (0.58, 0.58) 0.56 (0.54, 0.6) NA (NA, NA) 0.76 (0.72, 0.81) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 r_prob 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.33 (0.33, 0.33) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 rate 0.083 (0.08, 0.087) 0.071 (0.053, 0.089) 0.086 (0.086, 0.087) 0.092 (0.084, 0.1) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.056 (0.056, 0.056) 0.035 (0.007, 0.062) NA (NA, NA) 0.051 (0.045, 0.056) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Futility:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
all TC1 time 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6)
all TC1 n 18 (12, 20) 2 (2, 5) 0 (0, 2) 1 (0, 3) 4 (1, 4) 0 (0, 2) 1 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 1 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 0) 1 (0, 2) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.22 (0.12, 0.42) 0.42 (0.42, 0.48) NA (NA, NA) 0.44 (0.43, 0.45) 0.44 (0.42, 0.46) 0.37 (0.34, 0.4) 0.42 (0.42, 0.42) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.47 (0.45, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.48 (0.48, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.185 (0.119, 0.264) 0.31 (0.202, 0.385) 0 (0, 0) 0.279 (0.235, 2.411) 0.162 (0.095, 0.229) 1.544 (0.752, 2.335) 0 (0, 0.362) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.359 (0.359, 0.359) NA (NA, NA) 0 (0, 2.932) 0.563 (0.113, 1.013) 0 (0, 0) NA (NA, NA) 0.235 (0.047, 0.373) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
all TC2 time 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25) 11 (7, 25)
all TC2 n 28 (16, 50) 2 (0, 12) 1 (1, 3) 2 (1, 4) 6 (2, 10) 5 (2, 5) 0 (0, 1) 2 (1, 4) 2 (0, 7) 0 (0, 0) 1 (0, 1) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (1, 4) 0 (0, 2) 2 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 6 (4, 6) 3 (1, 5) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.25 (0.12, 0.42) 0.42 (0.4, 0.45) 0.35 (0.32, 0.38) 0.44 (0.39, 0.49) 0.31 (0.28, 0.38) 0.31 (0.18, 0.39) 0.4 (0.4, 0.4) 0.36 (0.29, 0.45) 0.38 (0.36, 0.39) NA (NA, NA) 0.44 (0.44, 0.44) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.4 (0.4, 0.4) NA (NA, NA) 0.34 (0.34, 0.34) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.38 (0.36, 0.43) 0.41 (0.37, 0.45) 0.24 (0.24, 0.24) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.123 (0.113, 0.185) 0.136 (0.117, 0.156) 0.167 (0.033, 0.19) 0.183 (0.037, 0.215) 0.205 (0.137, 3.042) 0.244 (0.183, 0.374) 0.442 (0.442, 0.442) 0.307 (0.234, 0.924) 0.213 (0.144, 0.282) NA (NA, NA) 0.169 (0.034, 0.304) 0.084 (0.084, 0.084) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0.166) 0.043 (0.043, 0.043) 0.241 (0.21, 0.272) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.143 (0.142, 0.175) 0.113 (0.095, 0.131) 0.24 (0.24, 0.24) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
all TC4 time 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24) 22 (19, 24)
all TC4 n 16 (10, 22) 2 (2, 3) 0 (0, 0) 2 (2, 2) 5 (5, 5) 9 (4, 14) 3 (2, 4) 4 (4, 5) 8 (7, 8) 0 (0, 0) 2 (1, 4) 2 (1, 2) 0 (0, 1) 0 (0, 1) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 2 (1, 2) 1 (1, 1) 0 (0, 0) 0 (0, 0) 6 (4, 8) 1 (1, 1) 2 (1, 2) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.35 (0.25, 0.46) 0.37 (0.27, 0.47) NA (NA, NA) 0.27 (0.25, 0.29) 0.28 (0.25, 0.31) 0.31 (0.26, 0.35) 0.31 (0.23, 0.39) 0.27 (0.22, 0.33) 0.21 (0.12, 0.3) NA (NA, NA) 0.43 (0.43, 0.44) 0.43 (0.43, 0.43) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.41 (0.4, 0.43) NA (NA, NA) NA (NA, NA) 0.39 (0.32, 0.46) 0.41 (0.4, 0.42) NA (NA, NA) NA (NA, NA) 0.41 (0.38, 0.43) 0.37 (0.34, 0.39) 0.39 (0.39, 0.4) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC4 rate 0.141 (0.139, 0.144) 0.2 (0.137, 0.262) NA (NA, NA) 0.411 (0.41, 0.411) 0.139 (0.139, 0.139) 0.158 (0.136, 0.181) 0.382 (0.249, 0.514) 0.23 (0.178, 0.283) 0.155 (0.137, 0.173) NA (NA, NA) 0.146 (0.095, 0.197) 0.814 (0.493, 1.135) 0 (0, 0) 0.178 (0.178, 0.178) NA (NA, NA) 1.468 (0.592, 2.345) NA (NA, NA) NA (NA, NA) 0.187 (0.121, 0.254) 0.334 (0.16, 0.508) NA (NA, NA) NA (NA, NA) 0.143 (0.137, 0.15) 0.819 (0.387, 1.251) 0.261 (0.17, 0.352) NA (NA, NA) 0.058 (0.058, 0.058) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 77 77 77 77 77 77 77 77
AR- & TP53- TC1 time 11 (6, 25) 11 (6, 25) 11 (6, 25) 11 (6, 25) 11 (6, 25) 11 (6, 25) 11 (6, 25) 11 (6, 25)
AR- & TP53- TC1 n 21 (16, 38) 4 (2, 10) 1 (0, 3) 2 (0, 5) 3 (0, 6) 0 (0, 0) 1 (0, 4) 0 (0, 2)
AR- & TP53- TC1 post_p 0.27 (0.12, 0.43) 0.35 (0.19, 0.46) 0.43 (0.31, 0.48) 0.42 (0.32, 0.49) 0.42 (0.23, 0.49) NA (NA, NA) 0.4 (0.29, 0.47) 0.43 (0.32, 0.48)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.134 (0.103, 0.172) 0.163 (0.105, 0.4) 0.17 (0, 0.545) 0.19 (0.073, 0.352) 0.183 (0.112, 0.608) 0.237 (0.237, 0.237) 0.224 (0, 0.638) 0.178 (0, 0.679)
AR- & TP53- TC2 count 61 61 61 61 61 61 61 61
AR- & TP53- TC2 time 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28)
AR- & TP53- TC2 n 19 (11, 35) 5 (2, 13) 1 (0, 4) 2 (1, 6) 4 (1, 9) 0 (0, 0) 2 (0, 6) 1 (0, 3)
AR- & TP53- TC2 post_p 0.3 (0.08, 0.45) 0.38 (0.18, 0.47) 0.4 (0.29, 0.46) 0.4 (0.28, 0.47) 0.37 (0.23, 0.49) NA (NA, NA) 0.4 (0.29, 0.48) 0.42 (0.27, 0.48)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.141 (0.107, 0.187) 0.155 (0.114, 0.359) 0.215 (0.093, 0.532) 0.194 (0.092, 0.597) 0.165 (0.104, 0.39) NA (NA, NA) 0.2 (0.087, 0.607) 0.183 (0.016, 0.468)
AR- & TP53- TC3 count 61 61 61 61 61 61 61 61
AR- & TP53- TC3 time 19 (13, 29) 19 (13, 29) 19 (13, 29) 19 (13, 29) 19 (13, 29) 19 (13, 29) 19 (13, 29) 19 (13, 29)
AR- & TP53- TC3 n 18 (8, 39) 5 (2, 11) 1 (0, 3) 3 (0, 4) 7 (3, 15) 0 (0, 0) 3 (2, 7) 1 (0, 3)
AR- & TP53- TC3 post_p 0.33 (0.17, 0.48) 0.36 (0.16, 0.48) 0.41 (0.31, 0.46) 0.4 (0.24, 0.48) 0.34 (0.19, 0.47) NA (NA, NA) 0.44 (0.27, 0.5) 0.4 (0.3, 0.48)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.131 (0.106, 0.174) 0.164 (0.091, 0.438) 0.259 (0.119, 0.686) 0.171 (0.114, 0.868) 0.156 (0.103, 0.265) 5.27 (1.054, 9.486) 0.169 (0.094, 0.395) 0.204 (0.076, 0.483)
AR- & TP53- TC4 count 53 53 53 53 53 53 53 53
AR- & TP53- TC4 time 17 (11, 30) 17 (11, 30) 17 (11, 30) 17 (11, 30) 17 (11, 30) 17 (11, 30) 17 (11, 30) 17 (11, 30)
AR- & TP53- TC4 n 18 (7, 36) 5 (2, 10) 1 (0, 2) 3 (0, 6) 6 (4, 12) 0 (0, 0) 4 (2, 6) 2 (0, 3)
AR- & TP53- TC4 post_p 0.29 (0.07, 0.45) 0.37 (0.24, 0.49) 0.39 (0.26, 0.47) 0.4 (0.28, 0.49) 0.32 (0.16, 0.48) NA (NA, NA) 0.38 (0.21, 0.47) 0.42 (0.33, 0.45)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.147 (0.114, 0.225) 0.154 (0.114, 0.371) 0.343 (0.075, 0.925) 0.198 (0.111, 0.638) 0.151 (0.102, 0.3) 0.168 (0.034, 0.302) 0.164 (0.111, 0.42) 0.203 (0.105, 0.773)
AR- & TP53- TC5 count 54 54 54 54 54 54 54 54
AR- & TP53- TC5 time 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28)
AR- & TP53- TC5 n 16 (6, 30) 7 (4, 13) 1 (0, 3) 4 (1, 8) 4 (1, 11) 0 (0, 0) 3 (0, 7) 1 (0, 3)
AR- & TP53- TC5 post_p 0.32 (0.08, 0.47) 0.33 (0.18, 0.44) 0.4 (0.31, 0.49) 0.37 (0.24, 0.49) 0.36 (0.24, 0.47) NA (NA, NA) 0.42 (0.28, 0.49) 0.42 (0.35, 0.48)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.139 (0.115, 0.233) 0.153 (0.111, 0.265) 0.244 (0.076, 1.916) 0.156 (0.085, 0.459) 0.191 (0.109, 0.405) 0.082 (0.016, 0.147) 0.146 (0.092, 0.439) 0.245 (0.13, 1.312)
HRD+ TC1 count 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12
HRD+ TC1 time 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35)
HRD+ TC1 n 12 (7, 17) 0 (0, 0) 4 (3, 9) 2 (1, 4) 0 (0, 0) 2 (0, 4) 0 (0, 0) 2 (0, 2) 2 (2, 5) 0 (0, 0) 0 (0, 3) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.44 (0.23, 0.49) NA (NA, NA) 0.35 (0.29, 0.47) 0.32 (0.18, 0.47) NA (NA, NA) 0.4 (0.34, 0.44) NA (NA, NA) 0.38 (0.34, 0.47) 0.32 (0.21, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.121 (0.098, 0.132) 0.26 (0.26, 0.26) 0.156 (0.121, 0.254) 0.24 (0.145, 0.488) NA (NA, NA) 0.226 (0.139, 0.479) NA (NA, NA) 0.217 (0.139, 1.473) 0.376 (0.137, 0.699) 0.173 (0.173, 0.173) 0.099 (0, 0.52) NA (NA, NA) 0.314 (0.275, 0.353) NA (NA, NA) NA (NA, NA) 1.17 (1.17, 1.17)
HRD+ TC2 count 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9
HRD+ TC2 time 35 (27, 36) 35 (27, 36) 35 (27, 36) 35 (27, 36) 35 (27, 36) 35 (27, 36) 35 (27, 36) 35 (27, 36) 35 (27, 36) 35 (27, 36) 35 (27, 36) 35 (27, 36) 35 (27, 36) 35 (27, 36) 35 (27, 36) 35 (27, 36)
HRD+ TC2 n 9 (3, 15) 0 (0, 0) 7 (3, 12) 3 (0, 5) 0 (0, 0) 1 (1, 4) 0 (0, 0) 1 (0, 2) 3 (2, 6) 0 (0, 0) 1 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.29 (0.16, 0.45) NA (NA, NA) 0.38 (0.29, 0.44) 0.41 (0.32, 0.47) NA (NA, NA) 0.45 (0.38, 0.48) NA (NA, NA) 0.37 (0.33, 0.46) 0.36 (0.27, 0.42) NA (NA, NA) 0.45 (0.36, 0.47) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.142 (0.111, 0.59) NA (NA, NA) 0.161 (0.095, 0.201) 0.152 (0.123, 16.614) NA (NA, NA) 0.122 (0, 0.2) NA (NA, NA) 0.108 (0.091, 0.514) 0.156 (0.123, 0.284) 0.106 (0.106, 0.106) 0.365 (0.083, 1.36) NA (NA, NA) 0.07 (0.057, 0.083) 0.525 (0.155, 0.894) NA (NA, NA) NA (NA, NA)
HRD+ TC3 count 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31
HRD+ TC3 time 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34)
HRD+ TC3 n 11 (8, 18) 0 (0, 0) 6 (3, 10) 2 (1, 5) 0 (0, 0) 1 (0, 2) 0 (0, 0) 1 (0, 4) 3 (2, 7) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.39 (0.19, 0.48) NA (NA, NA) 0.35 (0.21, 0.47) 0.4 (0.19, 0.48) NA (NA, NA) 0.42 (0.33, 0.48) NA (NA, NA) 0.46 (0.34, 0.49) 0.38 (0.18, 0.47) NA (NA, NA) 0.42 (0.37, 0.48) NA (NA, NA) 0.46 (0.46, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.127 (0.102, 0.175) 0 (0, 0) 0.165 (0.102, 0.272) 0.2 (0.09, 0.346) 0.966 (0.396, 1.537) 0.18 (0.064, 0.603) 0.362 (0.146, 0.577) 0.169 (0.055, 0.562) 0.147 (0.093, 0.511) 0.087 (0.075, 0.117) 0.204 (0.086, 0.699) 0.109 (0.109, 0.109) 0.231 (0, 0.637) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC4 count 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23
HRD+ TC4 time 29 (20, 35) 29 (20, 35) 29 (20, 35) 29 (20, 35) 29 (20, 35) 29 (20, 35) 29 (20, 35) 29 (20, 35) 29 (20, 35) 29 (20, 35) 29 (20, 35) 29 (20, 35) 29 (20, 35) 29 (20, 35) 29 (20, 35) 29 (20, 35)
HRD+ TC4 n 11 (6, 18) 0 (0, 0) 5 (3, 7) 2 (1, 4) 0 (0, 0) 1 (0, 5) 0 (0, 0) 2 (1, 6) 4 (1, 5) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.33 (0.1, 0.45) NA (NA, NA) 0.31 (0.15, 0.45) 0.43 (0.25, 0.49) NA (NA, NA) 0.37 (0.22, 0.47) NA (NA, NA) 0.41 (0.34, 0.48) 0.38 (0.28, 0.48) NA (NA, NA) 0.42 (0.41, 0.5) NA (NA, NA) 0.43 (0.43, 0.43) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.129 (0.108, 0.247) 0 (0, 0) 0.215 (0.123, 0.34) 0.169 (0.092, 0.673) 0.188 (0.038, 0.339) 0.3 (0.11, 1.24) NA (NA, NA) 0.178 (0.106, 0.391) 0.162 (0.12, 0.53) 0.03 (0, 0.242) 0.206 (0, 0.428) 0.164 (0.164, 0.164) 0.224 (0.075, 0.812) NA (NA, NA) 0.421 (0.421, 0.421) 0.047 (0.009, 0.085)
HRD+ TC5 count 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
HRD+ TC5 time 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35)
HRD+ TC5 n 12 (4, 16) 0 (0, 0) 4 (3, 9) 2 (1, 4) 0 (0, 0) 2 (0, 3) 0 (0, 0) 2 (0, 3) 2 (1, 5) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 post_p 0.28 (0.11, 0.48) NA (NA, NA) 0.37 (0.31, 0.44) 0.3 (0.24, 0.48) NA (NA, NA) 0.42 (0.38, 0.48) NA (NA, NA) 0.39 (0.34, 0.46) 0.44 (0.39, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 rate 0.131 (0.107, 0.35) 0 (0, 0) 0.152 (0.138, 0.217) 0.306 (0.135, 1.223) 0.65 (0.65, 0.65) 0.147 (0.045, 0.223) 0.103 (0.103, 0.103) 0.146 (0.105, 0.827) 0.139 (0.093, 0.259) NA (NA, NA) 0.306 (0.1, 3.837) NA (NA, NA) 0.861 (0.318, 1.929) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20
TP53+ TC1 time 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30)
TP53+ TC1 n 6 (4, 13) 6 (5, 11) 3 (1, 5) 5 (3, 8) 0 (0, 0) 1 (0, 2) 0 (0, 0) 1 (0, 2) 0 (0, 1) 0 (0, 0) 4 (3, 7) 3 (1, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.36 (0.15, 0.47) 0.34 (0.21, 0.43) 0.44 (0.32, 0.48) 0.43 (0.34, 0.48) NA (NA, NA) 0.4 (0.35, 0.46) NA (NA, NA) 0.43 (0.35, 0.49) NA (NA, NA) NA (NA, NA) 0.39 (0.19, 0.48) 0.36 (0.28, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.147 (0.099, 0.322) 0.164 (0.136, 0.254) 0.201 (0.114, 0.313) 0.147 (0.096, 0.217) 0.441 (0.441, 0.441) 0.153 (0, 0.586) NA (NA, NA) 0.244 (0.131, 0.866) 0.014 (0, 0.102) NA (NA, NA) 0.172 (0.086, 0.579) 0.197 (0.119, 1.677) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0)
TP53+ TC2 count 33 33 33 33 33 33 33 33 33 33 33 33 33 33 33 33
TP53+ TC2 time 19 (13, 28) 19 (13, 28) 19 (13, 28) 19 (13, 28) 19 (13, 28) 19 (13, 28) 19 (13, 28) 19 (13, 28) 19 (13, 28) 19 (13, 28) 19 (13, 28) 19 (13, 28) 19 (13, 28) 19 (13, 28) 19 (13, 28) 19 (13, 28)
TP53+ TC2 n 6 (4, 11) 4 (2, 10) 3 (0, 5) 4 (2, 8) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 2) 1 (0, 2) 0 (0, 0) 7 (3, 10) 3 (2, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.39 (0.19, 0.46) 0.36 (0.18, 0.46) 0.38 (0.25, 0.46) 0.37 (0.21, 0.47) NA (NA, NA) 0.4 (0.32, 0.46) NA (NA, NA) 0.43 (0.38, 0.48) 0.46 (0.42, 0.48) NA (NA, NA) 0.37 (0.21, 0.48) 0.37 (0.21, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.143 (0.107, 0.385) 0.179 (0.11, 0.341) 0.181 (0.072, 0.437) 0.151 (0.109, 0.37) 2.073 (2.073, 2.073) 0.185 (0, 0.419) 0.172 (0.172, 0.172) 0.221 (0.069, 7.503) 0.141 (0, 5.341) NA (NA, NA) 0.14 (0.093, 0.266) 0.176 (0.106, 0.652) 0 (0, 0) 0.122 (0.024, 0.195) 0.069 (0.069, 0.069) NA (NA, NA)
TP53+ TC3 count 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18
TP53+ TC3 time 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32)
TP53+ TC3 n 6 (3, 11) 4 (3, 10) 2 (0, 3) 4 (2, 6) 0 (0, 0) 1 (0, 4) 0 (0, 0) 1 (0, 2) 0 (0, 1) 0 (0, 0) 6 (3, 10) 5 (2, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.38 (0.21, 0.47) 0.34 (0.16, 0.46) 0.45 (0.27, 0.49) 0.34 (0.22, 0.44) NA (NA, NA) 0.43 (0.36, 0.46) NA (NA, NA) 0.44 (0.37, 0.48) 0.45 (0.43, 0.47) NA (NA, NA) 0.32 (0.18, 0.46) 0.37 (0.13, 0.48) 0.45 (0.45, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.136 (0.124, 0.27) 0.171 (0.1, 0.278) 0.19 (0.116, 0.523) 0.186 (0.132, 0.43) 0.073 (0.073, 0.073) 0.224 (0, 0.506) 0.429 (0.267, 0.591) 0.102 (0.074, 0.477) 0.406 (0.289, 4.927) NA (NA, NA) 0.137 (0.108, 0.408) 0.199 (0.111, 0.376) 0.192 (0.11, 0.273) NA (NA, NA) 2.103 (2.103, 2.103) NA (NA, NA)
TP53+ TC4 count 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24
TP53+ TC4 time 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35)
TP53+ TC4 n 6 (4, 15) 6 (2, 15) 2 (0, 5) 4 (2, 8) 0 (0, 1) 0 (0, 2) 0 (0, 0) 1 (0, 3) 0 (0, 1) 0 (0, 0) 4 (3, 12) 5 (2, 10) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.42 (0.34, 0.48) 0.33 (0.2, 0.44) 0.36 (0.26, 0.48) 0.27 (0.17, 0.46) NA (NA, NA) 0.41 (0.31, 0.47) NA (NA, NA) 0.4 (0.27, 0.49) 0.46 (0.41, 0.49) NA (NA, NA) 0.38 (0.19, 0.47) 0.37 (0.25, 0.46) 0.44 (0.44, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.139 (0.11, 0.169) 0.152 (0.107, 0.408) 0.216 (0.117, 0.74) 0.203 (0.153, 0.366) 0 (0, 15.405) 0.178 (0.008, 1.164) 0 (0, 0) 0.201 (0, 0.595) 0.304 (0.107, 1.357) NA (NA, NA) 0.145 (0.109, 0.42) 0.143 (0.109, 0.269) 0.183 (0, 4.523) 0 (0, 0) 0 (0, 0) 0.09 (0.09, 0.09)
TP53+ TC5 count 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28
TP53+ TC5 time 18 (13, 32) 18 (13, 32) 18 (13, 32) 18 (13, 32) 18 (13, 32) 18 (13, 32) 18 (13, 32) 18 (13, 32) 18 (13, 32) 18 (13, 32) 18 (13, 32) 18 (13, 32) 18 (13, 32) 18 (13, 32) 18 (13, 32) 18 (13, 32)
TP53+ TC5 n 6 (3, 11) 7 (4, 12) 2 (0, 3) 6 (3, 10) 0 (0, 0) 0 (0, 2) 0 (0, 0) 1 (0, 3) 0 (0, 1) 0 (0, 0) 3 (2, 7) 4 (2, 6) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.41 (0.19, 0.49) 0.37 (0.16, 0.48) 0.41 (0.29, 0.47) 0.4 (0.28, 0.48) NA (NA, NA) 0.4 (0.33, 0.47) NA (NA, NA) 0.46 (0.26, 0.49) 0.45 (0.41, 0.49) NA (NA, NA) 0.36 (0.19, 0.47) 0.33 (0.24, 0.47) 0.45 (0.44, 0.45) NA (NA, NA) 0.49 (0.49, 0.49) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.144 (0.101, 0.257) 0.145 (0.102, 0.236) 0.308 (0.146, 0.647) 0.134 (0.09, 0.231) NA (NA, NA) 0.328 (0.149, 0.538) 0.103 (0.103, 0.103) 0.232 (0.021, 0.801) 0.117 (0, 0.457) 0.317 (0.317, 0.317) 0.193 (0.109, 0.644) 0.172 (0.111, 0.433) 0.098 (0.021, 0.348) NA (NA, NA) 0.191 (0.191, 0.191) NA (NA, NA)
TEfus+ TC1 count 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11
TEfus+ TC1 time 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33)
TEfus+ TC1 n 1 (0, 4) 3 (2, 4) 1 (0, 2) 5 (2, 6) 2 (0, 4) 1 (0, 4) 0 (0, 0) 0 (0, 2) 3 (1, 5) 1 (0, 4) 5 (3, 10) 2 (1, 7) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.44 (0.41, 0.48) 0.4 (0.26, 0.47) 0.44 (0.4, 0.48) 0.26 (0.18, 0.47) 0.37 (0.33, 0.44) 0.42 (0.4, 0.49) NA (NA, NA) 0.43 (0.4, 0.47) 0.44 (0.41, 0.45) 0.44 (0.25, 0.47) 0.41 (0.36, 0.47) 0.39 (0.28, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.169 (0.102, 0.31) 0.17 (0.128, 0.359) 0.199 (0.095, 0.34) 0.259 (0.13, 0.325) 0.192 (0.129, 0.495) 0.2 (0.096, 0.353) NA (NA, NA) 0.271 (0.169, 0.306) 0.132 (0.075, 0.269) 0.239 (0.089, 0.689) 0.138 (0.107, 0.2) 0.21 (0.103, 1.591) 0.137 (0.027, 0.246) 0.157 (0.103, 0.211) 0 (0, 0) NA (NA, NA)
TEfus+ TC2 count 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14
TEfus+ TC2 time 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33)
TEfus+ TC2 n 2 (0, 4) 4 (1, 7) 3 (1, 5) 5 (2, 8) 2 (1, 5) 1 (0, 2) 0 (0, 0) 0 (0, 2) 2 (1, 4) 0 (0, 2) 6 (4, 10) 5 (2, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.37 (0.31, 0.45) 0.38 (0.2, 0.49) 0.37 (0.25, 0.45) 0.39 (0.21, 0.47) 0.41 (0.34, 0.49) 0.35 (0.29, 0.43) NA (NA, NA) 0.45 (0.35, 0.46) 0.35 (0.26, 0.46) 0.46 (0.37, 0.49) 0.34 (0.21, 0.45) 0.32 (0.2, 0.46) 0.4 (0.4, 0.4) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.25 (0.096, 1.813) 0.166 (0.121, 0.344) 0.163 (0.072, 0.618) 0.175 (0.094, 0.264) 0.195 (0.081, 0.939) 0.205 (0.128, 0.88) 0.331 (0.331, 0.331) 0.254 (0.081, 0.361) 0.228 (0.134, 0.473) 0.11 (0, 0.48) 0.161 (0.121, 0.244) 0.176 (0.115, 0.338) 0.198 (0.053, 0.423) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 count 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9
TEfus+ TC3 time 22 (19, 33) 22 (19, 33) 22 (19, 33) 22 (19, 33) 22 (19, 33) 22 (19, 33) 22 (19, 33) 22 (19, 33) 22 (19, 33) 22 (19, 33) 22 (19, 33) 22 (19, 33) 22 (19, 33) 22 (19, 33) 22 (19, 33) 22 (19, 33)
TEfus+ TC3 n 1 (0, 2) 3 (0, 6) 1 (0, 3) 5 (3, 13) 4 (2, 9) 2 (0, 6) 0 (0, 0) 1 (0, 2) 2 (1, 5) 0 (0, 1) 4 (2, 6) 2 (1, 7) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.38 (0.21, 0.48) 0.42 (0.26, 0.46) 0.42 (0.34, 0.48) 0.42 (0.27, 0.48) 0.37 (0.29, 0.46) 0.41 (0.3, 0.48) NA (NA, NA) 0.47 (0.39, 0.5) 0.45 (0.34, 0.49) 0.37 (0.25, 0.43) 0.34 (0.2, 0.46) 0.33 (0.22, 0.46) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.173 (0.111, 0.501) 0.174 (0.145, 0.326) 0.124 (0.067, 4.419) 0.142 (0.103, 0.402) 0.131 (0.116, 0.331) 0.242 (0.139, 0.375) NA (NA, NA) 0.135 (0.088, 0.227) 0.173 (0.108, 0.278) 0.467 (0.233, 0.663) 0.218 (0.117, 0.441) 0.181 (0.15, 0.571) 0.064 (0, 0.379) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11
TEfus+ TC4 time 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34)
TEfus+ TC4 n 1 (0, 2) 4 (1, 5) 2 (1, 4) 6 (4, 8) 4 (2, 7) 2 (0, 3) 0 (0, 0) 2 (0, 3) 3 (1, 4) 1 (0, 2) 4 (2, 8) 4 (1, 6) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.37 (0.35, 0.44) 0.37 (0.3, 0.47) 0.25 (0.17, 0.45) 0.27 (0.22, 0.49) 0.36 (0.16, 0.48) 0.44 (0.31, 0.46) NA (NA, NA) 0.44 (0.37, 0.48) 0.43 (0.31, 0.45) 0.45 (0.41, 0.49) 0.37 (0.19, 0.44) 0.38 (0.08, 0.48) 0.49 (0.36, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.31 (0.123, 2.713) 0.179 (0.112, 0.412) 0.258 (0.15, 0.519) 0.15 (0.094, 0.244) 0.176 (0.099, 0.472) 0.274 (0.144, 1.23) 0 (0, 0) 0.144 (0.081, 0.243) 0.143 (0.103, 0.419) 0.113 (0.084, 0.688) 0.207 (0.132, 0.379) 0.195 (0.093, 0.933) 0.187 (0.072, 1.937) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 count 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9
TEfus+ TC5 time 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32)
TEfus+ TC5 n 1 (0, 3) 6 (2, 8) 3 (1, 3) 5 (4, 8) 3 (1, 5) 1 (0, 2) 0 (0, 0) 1 (0, 2) 1 (0, 5) 2 (0, 3) 4 (2, 9) 4 (3, 7) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p 0.43 (0.35, 0.49) 0.27 (0.2, 0.41) 0.39 (0.2, 0.42) 0.38 (0.05, 0.43) 0.38 (0.3, 0.49) 0.4 (0.35, 0.44) NA (NA, NA) 0.43 (0.4, 0.46) 0.39 (0.36, 0.46) 0.42 (0.32, 0.45) 0.28 (0.11, 0.44) 0.31 (0.26, 0.43) 0.38 (0.34, 0.42) NA (NA, NA) 0.49 (0.49, 0.49) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 0.139 (0.082, 0.592) 0.174 (0.142, 0.582) 0.223 (0.14, 0.289) 0.139 (0.118, 0.364) 0.237 (0.086, 1.008) 0.188 (0.116, 0.445) NA (NA, NA) 0.381 (0.122, 0.489) 0.225 (0.108, 0.499) 0.191 (0.109, 0.331) 0.222 (0.139, 0.556) 0.174 (0.111, 0.246) 0.388 (0.183, 0.5) NA (NA, NA) 0.191 (0.191, 0.191) NA (NA, NA)
PI3K+ TC1 count 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22
PI3K+ TC1 time 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32)
PI3K+ TC1 n 7 (3, 13) 3 (1, 6) 8 (4, 17) 4 (1, 7) 0 (0, 0) 1 (0, 3) 1 (0, 2) 1 (0, 3) 0 (0, 2) 2 (0, 3) 0 (0, 0) 5 (1, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.38 (0.14, 0.47) 0.4 (0.3, 0.48) 0.39 (0.19, 0.47) 0.35 (0.24, 0.49) NA (NA, NA) 0.36 (0.25, 0.48) 0.43 (0.37, 0.49) 0.44 (0.34, 0.48) 0.44 (0.32, 0.46) 0.45 (0.36, 0.47) NA (NA, NA) 0.38 (0.22, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.141 (0.1, 0.296) 0.169 (0.101, 0.465) 0.145 (0.109, 0.241) 0.16 (0.099, 0.488) 0.26 (0.26, 0.26) 0.25 (0.106, 0.645) 0.286 (0.098, 1.218) 0.196 (0.122, 0.393) 0.409 (0.053, 1.417) 0.185 (0.072, 0.431) 0.217 (0.217, 0.217) 0.17 (0.116, 0.665) 0.173 (0.173, 0.173) 0 (0, 0) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20
PI3K+ TC2 time 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31)
PI3K+ TC2 n 8 (4, 14) 3 (1, 6) 5 (2, 9) 3 (2, 9) 0 (0, 0) 0 (0, 3) 1 (0, 2) 0 (0, 1) 1 (0, 3) 1 (0, 3) 0 (0, 0) 5 (2, 12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.42 (0.23, 0.46) 0.34 (0.19, 0.46) 0.34 (0.21, 0.45) 0.36 (0.23, 0.49) NA (NA, NA) 0.43 (0.38, 0.49) 0.43 (0.34, 0.46) 0.44 (0.36, 0.46) 0.42 (0.32, 0.47) 0.43 (0.39, 0.48) NA (NA, NA) 0.39 (0.26, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.125 (0.105, 0.205) 0.218 (0.119, 0.72) 0.149 (0.119, 0.273) 0.201 (0.087, 0.684) NA (NA, NA) 0.262 (0.092, 0.817) 0.141 (0, 0.29) 0.264 (0.11, 1.155) 0.105 (0, 0.516) 0.14 (0.119, 0.382) NA (NA, NA) 0.134 (0.102, 0.209) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA)
PI3K+ TC3 count 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15
PI3K+ TC3 time 23 (19, 29) 23 (19, 29) 23 (19, 29) 23 (19, 29) 23 (19, 29) 23 (19, 29) 23 (19, 29) 23 (19, 29) 23 (19, 29) 23 (19, 29) 23 (19, 29) 23 (19, 29) 23 (19, 29) 23 (19, 29) 23 (19, 29) 23 (19, 29)
PI3K+ TC3 n 6 (2, 13) 4 (1, 6) 6 (3, 14) 3 (1, 8) 0 (0, 0) 2 (0, 7) 1 (0, 3) 1 (0, 2) 0 (0, 1) 1 (0, 2) 0 (0, 0) 5 (3, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.3 (0.16, 0.43) 0.4 (0.27, 0.48) 0.37 (0.2, 0.48) 0.38 (0.28, 0.47) NA (NA, NA) 0.4 (0.32, 0.43) 0.46 (0.45, 0.48) 0.42 (0.37, 0.43) 0.41 (0.38, 0.44) 0.41 (0.37, 0.48) NA (NA, NA) 0.37 (0.13, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.143 (0.105, 0.421) 0.159 (0.116, 0.29) 0.162 (0.108, 0.316) 0.187 (0.131, 0.95) NA (NA, NA) 0.185 (0.079, 0.273) 0.103 (0.063, 0.621) 0.271 (0.14, 4.682) 0.271 (0.268, 0.346) 0.24 (0.113, 0.857) NA (NA, NA) 0.185 (0.102, 0.282) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 count 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18
PI3K+ TC4 time 24 (17, 31) 24 (17, 31) 24 (17, 31) 24 (17, 31) 24 (17, 31) 24 (17, 31) 24 (17, 31) 24 (17, 31) 24 (17, 31) 24 (17, 31) 24 (17, 31) 24 (17, 31) 24 (17, 31) 24 (17, 31) 24 (17, 31) 24 (17, 31)
PI3K+ TC4 n 4 (2, 16) 3 (1, 7) 5 (3, 11) 5 (2, 10) 0 (0, 0) 2 (0, 4) 1 (0, 3) 1 (0, 4) 1 (0, 2) 1 (0, 2) 0 (0, 0) 4 (1, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC4 post_p 0.28 (0.18, 0.47) 0.36 (0.28, 0.43) 0.35 (0.19, 0.46) 0.34 (0.17, 0.44) NA (NA, NA) 0.44 (0.34, 0.47) 0.47 (0.37, 0.5) 0.42 (0.37, 0.48) 0.43 (0.4, 0.46) 0.44 (0.37, 0.49) NA (NA, NA) 0.35 (0.24, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.235 (0.117, 0.606) 0.215 (0.091, 0.51) 0.164 (0.124, 0.298) 0.179 (0.123, 0.539) NA (NA, NA) 0.213 (0.14, 0.662) 0.086 (0.064, 0.318) 0.168 (0, 1.343) 0.194 (0.073, 0.688) 0.21 (0.113, 0.669) NA (NA, NA) 0.173 (0.099, 0.946) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 count 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29
PI3K+ TC5 time 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28) 16 (10, 28)
PI3K+ TC5 n 7 (4, 12) 4 (3, 7) 6 (3, 13) 5 (3, 8) 0 (0, 0) 1 (0, 2) 0 (0, 1) 1 (0, 1) 0 (0, 2) 1 (0, 3) 0 (0, 0) 4 (2, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 post_p 0.39 (0.16, 0.46) 0.39 (0.22, 0.49) 0.38 (0.17, 0.47) 0.4 (0.19, 0.49) NA (NA, NA) 0.43 (0.39, 0.49) 0.45 (0.34, 0.49) 0.45 (0.38, 0.47) 0.46 (0.44, 0.47) 0.42 (0.3, 0.43) NA (NA, NA) 0.34 (0.24, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 r_prob 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.33 (0.33, 0.33) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 rate 0.145 (0.098, 0.303) 0.144 (0.092, 0.308) 0.136 (0.096, 0.27) 0.15 (0.091, 0.299) 0.164 (0.164, 0.164) 0.238 (0, 0.522) 0.214 (0.066, 0.358) 0.355 (0.044, 1.521) 0.135 (0.047, 0.997) 0.243 (0.06, 0.579) NA (NA, NA) 0.195 (0.101, 0.339) 0.137 (0.137, 0.137) 0 (0, 0) NA (NA, NA) NA (NA, NA)